Interaction Details

There were no interactions found between Donepezil and Alpha-alanine. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.


Still looking for more information about combining Donepezil and Alpha-alanine? Ask Dr. Brian Staiger about it by contacting him directly.

Alpha-alanine Overview

Alpha-alanine Alanine, a non-essential amino acid, has two forms: L-alpha-alanine and D-alpha-alanine. L-alpha-alanine is vital in protein synthesis and gluconeogenesis, sourced from diet, amino acid conversion, and glucose metabolism. It stimulates glucagon secretion, raising blood glucose levels in type 1 diabetes without affecting C-peptide or insulin. Conversely, in non-diabetics, it balances glucose levels. Animal studies suggest L-alpha-alanine may improve glutathione levels, enhance electrolyte absorption, reduce ketosis after exertion, and impact glycogen storage disease type II. D-alpha-alanine is explored for neurological effects, acting as an NMDA receptor agonist.
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Donepezil Overview

  • Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people who have Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, the ability to interact with others, speak, think clearly, and perform regular daily activities) by increasing the amount of a certain naturally occurring substance in the brain. Donepezil may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, donepezil will not cure AD or prevent the loss of mental abilities at some time in the future.

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Alpha-alanine - More Interactions

Alpha-alanine interacts with 0 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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