Interaction Details

Bedaquiline is classified as belonging to the following category: Qt Interval-Prolonging Drugs

Arsenic trioxide can prolong the QT interval.
Up to 40% of patients treated with prescription arsenic trioxide have a prolonged QT interval on their electrocardiogram (ECG). Theoretically, non-prescription arsenic could have an additive effect when combined with drugs that prolong the QT interval.

Interaction Rating

Major

Likelihood of Occurrence

Probable

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.

References

  • McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

Arsenic Overview

Arsenic Arsenic is a trace element naturally present in the diet, with organic forms being generally non-toxic in low amounts, while inorganic forms can be harmful. It is found in foods such as seafood, poultry, grains (especially rice), bread, cereal products, mushrooms, and dairy. The estimated daily intake of organic arsenic is 12-50 mcg, with a suggested requirement of 12-25 mcg daily, while inorganic arsenic intake is estimated at 3.5-10 mcg daily. Arsenic plays a potential role in metabolism, the recycling of methionine, taurine function, and the regulation of gene expression in the body. In traditional Chinese medicine, arsenic has been used to treat various inflammatory disorders, but it is generally only found in homeopathic preparations.
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Bedaquiline Overview

  • Bedaquiline is used along with at least three other medications to treat multi-drug resistant tuberculosis (MDR-TB; a serious infection that affects the lungs and other parts of the body and that cannot be treated with other medications that are usually used to treat the condition) in adults and children 5 years and older who weigh at least 33 lbs (15 kg) that has affected the lungs. Bedaquiline should not be used to treat TB that mainly affects other parts of the body. Bedaquiline is in a class of medications called anti-mycobacterials. It works by killing the bacteria that cause MDR-TB.

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Arsenic - More Interactions

Arsenic interacts with 157 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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