Docosahexaenoic Acid (dha) - Defitelio (Defibrotide Sodium) Interaction
Herbal: Docosahexaenoic Acid (dha)
Also Known As: ADH, DHA, Fish Oil Fatty Acid, N-3 Fatty Acid, Neuromins, Omega 3, Omega 3 Fatty Acids, Omega-3, Omega-3 Fatty Acids, W-3 Fatty Acid
Drug: Defibrotide Sodium
Brand names:
Defitelio
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Defibrotide Sodium is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
References
- Leng GC, Smith FB, Fowkes FG, et al. Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors. Prostaglandins Leukot Essent Fatty Acids 1994;51:101-8.
- Nelson GJ, Schmidt PS, Bartolini GL, et al. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids 1997;32:1129-36.
- Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Barden, A., Watts, G. F., and Beilin, L. J. Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients
Docosahexaenoic Acid (dha) Overview
DHA (docosahexaenoic acid) is an omega-3 fatty acid that is important for the proper functioning of the nervous system and eyes.
DHA can be found in a variety of foods and in abundance in many different types of fatty fish, such as salmon and mackerel. It is a popular dietary supplement, consistently among the most utilized.
There is some evidence to suggest that DHA may have a number of potential health benefits, including improving cognitive function and reducing the risk of age-related cognitive decline. It has also been shown to be important for fetal and infant brain development and is a common component in prenatal vitamins.
DHA is often combined with EPA (eicosapentaenoic acid) in dietary supplements and both are found together in most fish-sourced ones. One main difference between DHA and EPA is their structure. DHA is a long-chain fatty acid, while EPA is a medium-chain fatty acid. This difference in structure may affect how they are utilized in the body and their potential health benefits. For example, DHA is more highly concentrated in the brain and is believed to be important for brain and eye health, while EPA is more highly concentrated in the heart and may be helpful in reducing inflammation and improving cardiovascular health.
Defibrotide Sodium Overview
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Defibrotide injection is used to treat adults and children with hepatic veno-occlusive disease (VOD; blocked blood vessels inside the liver, also known as sinusoidal obstruction syndrome), who have kidney or lung problems after receiving a hematopoietic stem-cell transplant (HSCT; procedure in which certain blood cells are removed from the body and then returned to the body). Defibrotide injection is in a class of medications called antithrombotic agents. It works by preventing the formation of blood clots.
Docosahexaenoic Acid (dha) - More Interactions
Docosahexaenoic Acid (dha) interacts with 367 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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