D-mannose Interactions Overview
Check For Interactions With D-mannose
D-mannose
- Carubinose
- D-Manosa
- Mannose
- Seminose
D-mannose is a sugar that is closely related to glucose and is naturally occurring in some fruits and vegetables. D-mannose is often taken as a supplement for its potential health benefits, particularly for urinary tract health. Some people use D-mannose to prevent urinary tract infections (UTIs) or to treat them once they occur. It is believed to work by preventing bacteria, such as E.coli, from adhering to the walls of the urinary tract. It's also thought that D-mannose can change the pH of urine making it less favorable for bacteria to survive. In dietary supplements, it is often combined with cranberry.
Additional Details
Is D-Mannose Safe? Are There Any Warnings?
D-Mannose, a sugar found in fruits and the human body, is generally considered safe for short-term use. Daily doses of 3 grams for up to 2 weeks or 2 grams for up to 6 months have shown apparent safety in research. However, the safety of long-term use and its effects during pregnancy and lactation remain uncertain.
How Does D-Mannose Work? What is the Mechanism of Action?
D-Mannose, a 6-carbon sugar, plays a crucial role in protein glycosylation and fibroblast activity in the body. It is rapidly absorbed and transported by mannose-specific transporters. In cases of a genetic deficiency called carbohydrate-deficient glycoprotein syndrome type 1b, supplemental D-Mannose seems to compensate for the deficiency, preventing protein loss and associated complications.
Specifically, for urinary tract health, D-Mannose may interfere with the adhesion of bacteria like Escherichia coli to the urinary tract lining. By binding to these bacteria, D-Mannose helps eliminate them during urination, potentially reducing the risk of urinary tract infections (UTIs).
Pharmacokinetics
When taken orally, supplemental D-Mannose is rapidly absorbed from the gastrointestinal tract. It is present in small amounts in the blood and reaches peripheral organs within about 30 minutes. Unlike glucose, D-Mannose is not stored in the body and is excreted in the urinary tract following supplementation.
Interaction Overview
Drugs: No known interactions.
Supplements: No known interactions.
Conditions: No known interactions.
Lab Tests: No known interactions.
Common Side Effects to Watch For
While generally well-tolerated, common side effects of orally administered D-Mannose include bloating, diarrhea, and nausea.
Are Supplements Standardized?
D-Mannose is commonly available in powder formulations, dissolved in water for consumption in clinical research.
What is D-Mannose Typically Used For?
Research suggests that D-Mannose is likely effective in preventing complications in carbohydrate-deficient glycoprotein syndrome type 1b. It may also play a role in reducing the recurrence of UTIs, either alone or in combination with other ingredients. However, more evidence is needed to establish its effectiveness for these purposes.
Drugs that interact with D-mannose
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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