Indian Gooseberry Interactions Overview

Additional Details

Is Indian Gooseberry Safe? Are There Any Warnings?

Indian gooseberry is generally considered safe when consumed in typical food amounts. When used medicinally in appropriate doses, both orally and topically, it is also deemed safe. However, caution is advised during pregnancy and lactation due to insufficient reliable information. Overall, Indian gooseberry appears well-tolerated, with limited adverse effects reported.

How Is Indian Gooseberry Thought To Work? What Is the Mechanism of Action?

Indian gooseberry operates through a variety of mechanisms:

• Constituents: The fruit contains vitamin C, gallic acid, flavonoids, and tannins like emblicanin-A and emblicanin-B.
• Anticancer Effects: Demonstrated in reducing tumor size and increasing survival in mice.
• Anti-inflammatory Effects: Noted in reducing C-reactive protein levels and modulating interleukin levels in humans.
• Antioxidant Effects: Tannins in Indian gooseberry increase antioxidant enzyme concentrations in rats.
• Cardiovascular Effects: Clinical research suggests positive impacts on cholesterol levels and cardiovascular markers.
• Coagulation Effects: Inhibits platelet aggregation, potentially impacting coagulation.
• Dental Effects: Chewing gum with Indian gooseberry extract increases saliva flow and reduces pathogenic bacteria.
• Endocrine Effects: Reduces inflammatory cytokines, potentially addressing insulin resistance.
• Gastroprotective Effects: Shows protective effects in alcohol-induced gastric ulcers in animal experiments.
• Immunomodulatory Effects: Inhibits certain immune responses, suggesting immunomodulatory properties.

Pharmacokinetics

Unfortunately, reliable information about the pharmacokinetics of Indian gooseberry is currently insufficient, warranting further study to understand how the body processes this substance.

Interaction Overview

When considering interactions, it's crucial to note potential moderate interactions with anticoagulant/antiplatelet drugs and antidiabetes drugs. Caution is advised when combining Indian gooseberry with aspirin and clopidogrel. Additionally, interactions with supplements affecting bleeding, copper, and hypoglycemia are possible.

Common Side Effects To Watch For

Orally, Indian gooseberry is generally well-tolerated, with limited reported side effects. Dermatologic, gastrointestinal, hepatic, musculoskeletal, neurologic/CNS, and pulmonary/respiratory side effects are not commonly associated with its use.

Are Supplements Standardized?

Various formulations of Indian gooseberry exist, with some standardized extracts containing specific percentages of polyphenols, triterpenoids, and oil. However, the standardization may vary depending on the product and manufacturer.

What Is Indian Gooseberry Typically Used For?

Indian gooseberry has been traditionally used for a range of health issues, including ophthalmic, cardiovascular, gastrointestinal, liver, and joint problems. It has also been employed for addressing gonorrhea, menstrual irregularities, dyslipidemia, and symptoms of GERD. While research is ongoing, potential uses include its application in cancer, cardiovascular disease, diabetes, hangover prevention, and more.

Drugs that interact with Indian Gooseberry