Zizyphus Interactions Overview

Check For Interactions With Zizyphus

Zizyphus

Also known as
  • Ziziphus jujuba
  • Anèbe
  • Annab
  • Azufaifo
  • Badar
  • Ber
  • Black Date
  • Black Jujube
  • Chinese Date
  • Chinese Jujube
  • Da Zao
  • Date Seed
  • Datte Chinoise
  • Datte Noire
  • Fructus Jujubae
  • Fructus Ju Jubae
  • Hei Zao
  • Hong Zao
  • Jujube
  • Jujube Chinois
  • Jujube Plum
  • Jujube Noir
  • Jujube Rouge
Zizyphus Zizyphus is a genus of trees and shrubs belonging to the buckthorn family (Rhamnaceae). There are several species of Zizyphus, including Zizyphus jujuba, Zizyphus lotus, and Zizyphus mauritiana. These are all traditionally associated with common names (such as Zizyphus jujuba being known as the Chinese date or red date). In traditional medicine, the leaves, bark, and fruit of Zizyphus species are used to treat a variety of conditions, including insomnia, anxiety, and digestive problems. Most commonly, the fruit, which is edible and resembles a date, is used. It is rich in fiber, vitamin C, B vitamins, and some fatty acids.
There are 464 drugs known to interact with Zizyphus

Additional Details

Is Zizyphus Safe? Are There Any Warnings?

Zizyphus fruit is considered generally safe when consumed in amounts typically found in foods. When used orally and appropriately in short-term doses, zizyphus fruit or seed extracts are also considered safe. However, there is insufficient information available regarding its safety when used topically. During pregnancy and lactation, zizyphus fruit consumption in typical amounts is likely safe, but information about its safety in higher amounts is lacking.

How Is Zizyphus Thought To Work? What Is the Mechanism of Action?

Zizyphus, a thorny shrub or small tree, has been used in traditional Chinese medicine for centuries. Its fruit contains various components like fatty acids, vitamins, minerals, and various phytochemicals, including flavonoids and triterpenic acids. Zizyphus has been associated with analgesic, anti-inflammatory, antioxidant, antimicrobial, neuroprotective, hepatoprotective, immunomodulatory, cardiovascular, and gastrointestinal effects in laboratory studies. However, more research is necessary to fully understand the mechanisms of action involved in these effects.

Pharmacokinetics

There is insufficient reliable information available about the pharmacokinetics of zizyphus. Further studies are required to understand how the body absorbs, metabolizes, and eliminates the components of zizyphus.

Interaction Overview (See Below For Full List)

Zizyphus is generally safe without any known major interactions with drugs or supplements. However, caution should be exercised when combining zizyphus with antidiabetes drugs, CNS depressants, and drugs metabolized by cytochrome P450 1A2. It is advisable to consult with a healthcare professional before combining zizyphus with other medications or supplements to ensure safety and efficacy.

Common Adverse Effects

Zizyphus fruit extract and powder are generally well tolerated without any commonly reported adverse effects. However, possible gastrointestinal and neurologic/CNS effects have been mentioned, although specific details are not provided. As with any supplement or herb, individual sensitivities and allergies may occur, therefore monitoring for any adverse reactions is essential.

Are Supplements Standardized?

Information about the standardization of zizyphus supplements is currently insufficient. It is advised to choose reputable brands that adhere to quality control measures and manufacturing standards to ensure the quality, purity, and potency of zizyphus products.

What Is Zizyphus Typically Used For?

Zizyphus has been traditionally used for various purposes, including aging skin, anemia of chronic disease, anxiety, asthma, cancer, constipation, diabetes, diarrhea, epilepsy, hyperlipidemia, hypertension, insomnia, neonatal jaundice, peptic ulcers, wound healing, and others. However, there is limited reliable evidence available to support the effectiveness of zizyphus for these uses. More research is needed to establish its therapeutic potential and specific applications.

It is important to consult with a healthcare professional before using zizyphus for any specific condition or purpose.

Drugs that interact with Zizyphus

Return to the main herbal interaction checker page

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC