Interaction Details

There were no interactions found between Cabozantinib and Lion's Mane Mushroom. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.


Still looking for more information about combining Cabozantinib and Lion's Mane Mushroom? Ask Dr. Brian Staiger about it by contacting him directly.

Lion's Mane Mushroom Overview

Lion's Mane Mushroom Lion's mane mushroom (Hericium erinaceus) is a type of edible mushroom that grows on the dead trunks of several species of hardwood tree and is native to North America, Europe, and Asia. It is named for its long, shaggy spines that resemble the mane of a lion. Lion's mane mushroom has been used as a dietary supplement for a number of purported health benefits. It is rich in antioxidants and may have anti-inflammatory properties, which may help to reduce the risk of chronic diseases such as heart disease. It is also believed to have neuroprotective effects and may help to improve cognitive function and memory, which is why it is often marketed as a 'nootropic'. In addition, lion's mane mushroom may have immune-boosting properties and may help to reduce the severity of colds and other infections.
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Cabozantinib Overview

  • Cabozantinib (Cabometyx, Cometriq) is used to treat a number of conditions.

  • Cabozantinib (Cabometyx) is used:

    • to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the cells of the kidneys).

    • in combination with nivolumab (Opdivo) to treat advanced RCC in patients who have not yet received a treatment for RCC.

    • to treat hepatocellular carcinoma (HCC; a type of liver cancer) in people who were previously treated with sorafenib (Nexafar).

    • to treat a certain type of thyroid cancer in adults and children 12 years of age and older that has spread to nearby tissues or to other parts of the body and that has not responded to previous a treatment and cannot be treated with radioactive iodine.

  • Cabozantinib (Cometriq) is used:

    • to treat a certain type of thyroid cancer that is getting worse and that has spread to other parts of the body.

  • Cabozantinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

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Lion's Mane Mushroom - More Interactions

Lion's Mane Mushroom interacts with 202 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Ask A Pharmacist About Your Herbal Questions!

Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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