Motherwort - Fentanyl Interaction
Herbal: Motherwort
Also Known As: Leonurus cardiac, Agripalma, Agripaume, Agripaume Cardiaque, Cardiaire, Cardiaque, Cheneuse, Chinese Motherwort, Common Motherwort, Creneuse, Herba Leonuri, Herbe aux Tonneliers, Hjärtstilla, Leonuri Cardiacae Herba, Leonurus, Leonurus Cardica, Lion's Ear, Lion's Tail, Mot
Drug: Fentanyl
Brand names:
Sublimaze, Duragesic, Fentora, Lazanda, Abstral, Subsys
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Fentanyl is classified as belonging to the following category: Cns Depressants
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
Motherwort Overview
Motherwort (Leonurus cardiaca) is a perennial herb native to Europe and Asia. Belonging to the mint family, the plant has a strong, pungent aroma and is often used in traditional medicine to treat a variety of ailments.
Motherwort is purported to have a number of medicinal properties, such as sedative, anti-anxiety, and anti-inflammatory effects, and has been used to treat conditions such as anxiety, insomnia, and heart palpitations. It is also sometimes used to treat menstrual regularity and to ease menopausal symptoms.
Dietary supplements containing motherwort are often marketed towards women to support their reproductive system and support healthy levels of stress.
Fentanyl Overview
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Fentanyl is used to treat breakthrough pain (sudden episodes of pain that occur despite round the clock treatment with pain medication) in cancer patients at least 18 years of age (or at least 16 years of age if using Actiq brand lozenges) who are taking regularly scheduled doses of another narcotic (opiate) pain medication, and who are tolerant (used to the effects of the medication) to narcotic pain medications. Fentanyl is in a class of medications called narcotic (opiate) analgesics. It works by changing the way the brain and nervous system respond to pain.
Motherwort - More Interactions
Motherwort interacts with 247 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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