Interaction Details

Larotrectinib is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates

Rooibos might increase the concentration and the effects of cytochrome P450 3A4 (CYP3A4) substrates. In vitro research shows that the methanol extract of rooibos leaves and stems strongly inhibits CYP3A4 enzymes.
Some drugs metabolized by CYP3A4 include atorvastatin (Lipitor), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), midazolam (Versed), and many others.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • Fantoukh OI, Dale OR, Parveen A, et al. Safety Assessment of Phytochemicals Derived from the Globalized South African Rooibos Tea (Aspalathus linearis) through Interaction with CYP, PXR, and P-gp. J Agric Food Chem. 2019;67(17):4967-4975.
  • Patel O, Muller CJF, Joubert E, et al. Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats. Front Pharmacol. 2019;10:1243.

Rooibos Overview

Rooibos Rooibos is a plant that is native to South Africa. The leaves and stems of the rooibos plant are used to make a tea, which has a unique, slightly sweet flavor and is known for its soothing properties. It is caffeine-free and high in antioxidants. Rooibos tea has been used in traditional medicine for the treatment of age-related cognitive decline, hay fever, anxiety, cardiovascular disease (CVD), diabetes, gastrointestinal disorders, inflammatory conditions and obesity. Research of rooibos extracts indicate it contains over 187 different compounds, some of which may have medicinal effects.
See More Information Regarding Rooibos

Larotrectinib Overview

  • Larotrectinib is used to treat a certain type of solid tumors in adults, children, and infants 4 weeks of age and older that have spread to other parts of the body or cannot be treated successfully with surgery. This medication is used only if there are no other treatments available and the tumors have worsened after receiving other treatments. Larotrectinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that tells the cancer cells to multiply. This may help slow the growth of tumors.

See More Information Regarding Larotrectinib

Rooibos - More Interactions

Rooibos interacts with 834 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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