Dactinomycin

20 interactions 142 cited references
Also sold as: Cosmegen Cosmegen®
About Dactinomycin

Dactinomycin is used in combination with other medications, surgery, and/or radiation therapy to treat Wilms' tumor (a type of kidney cancer that occurs in children) and rhabdomyosarcoma (cancer that forms in muscles) in children. Dactinomycin is also used in combination with other medications to treat certain types of… Read the full Dactinomycin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Measles Virus Vaccine, Live
9 Contraindicated 11 Major
All (20) Contraindicated (9) Major (11)

Contraindicated

Dactinomycin Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Dactinomycin Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Dactinomycin Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Dactinomycin Azathioprine Azasan An increased risk of hepatotoxicity Details Dactinomycin Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Dactinomycin Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Dactinomycin Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Dactinomycin Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Dactinomycin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Dactinomycin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dactinomycin Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Dactinomycin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.