Probenecid

59 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Probenecid Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details Probenecid Acetaminophen Acephen Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details Probenecid Acetaminophen Injection Acephen Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details Probenecid Acetaminophen Rectal Acephen Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details Probenecid Amoxicillin Amoxi Drop Prolonged and increased amoxicillin exposure Details Probenecid Aztreonam Injection Azactam Increased risk of aztreonam exposure Details Probenecid Belinostat Injection Beleodaq Increased belinostat exposure and an increased risk of belinostat-related adverse reactions Details Probenecid Baricitinib Olumiant Increased baricitinib exposure Details Probenecid Cephalexin Keflet® Tablets Increased cephalexin exposure Details Probenecid Deferiprone Ferriprox Reduced deferiprone clearance and increased deferiprone plasma concentrations Details Probenecid Doripenem Injection Doribax® Increased plasma concentrations of doripenem Details Probenecid Furosemide Injection Disal Altered furosemide exposure and reduced furosemide effectiveness Details Probenecid Glimepiride Amaryl Increased oral sulfonylureas exposure and an increased risk of hypoglycemia Details Probenecid Glipizide Glucotrol Increased oral sulfonylureas exposure and an increased risk of hypoglycemia Details Probenecid Irinotecan Camptosar Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details Probenecid Irinotecan Injection Camptosar Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details Probenecid Irinotecan Lipid Complex Injection Onivyde® Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details Probenecid Ketoprofen Actron® Increased risk of ketoprofen exposure and an increased risk of ketoprofen side effects (dizziness, drowsiness, tinnitus, renal fun... Details Probenecid Meclofenamate Meclodium® Increased risk of meclofenamate exposure and an increased risk of meclofenamate-related adverse reactions Details Probenecid Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Probenecid Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Probenecid Naproxen Aleve Increased naproxen exposure Details Probenecid Pegloticase Injection Krystexxa Increased risk of anaphylaxis and infusion reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.