Acacia Rigidula - Estradiol Interaction
Herbal: Acacia Rigidula
Also Known As: Vachellia rigidula, Acacia rigidula, Acaciopsis rigidula, Blackbrush, Blackbush, Chaparro Prieto
Drug: Estradiol
Brand names:
Estrace, Gynodiol, Vagifem, Estring, Vivelle, Estraderm, Divigel, Evamist, Elestrin, Minivelle, Imvexxy, Oestrogel
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Estradiol is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Beta-methylphenylethylamine (BMPEA), a constituent found in some Acacia rigidula products, inhibits cytochrome P450 3A4 (CYP3A4) enzymes in vitro by 37%. Theoretically, Acacia rigidula might increase the levels of CYP3A4 substrates. Drugs that might be affected include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, cisapride (Propulsid), alfentanil (Alfenta), fentanyl (Sublimaze), losartan (Cozaar), fluoxetine (Prozac), midazolam (Versed), omeprazole (Prilosec), ondansetron (Zofran), propranolol (Inderal), fexofenadine (Allegra), and numerous others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10.
Acacia Rigidula Overview
Acacia rigidula is a species of acacia tree native to Texas and Mexico. The plant is known for its small, bright yellow flowers and its woody, thorny branches.
Acacia rigidula has been traditionally used for medicinal purposes and is available as a dietary supplement marketed for weight loss aid and as a stimulant. It is purported to boost energy, increase metabolism, and aid weight loss.
Studies have found several active compounds in Acacia rigidula, including phenylethylamine (PEA) and its derivatives, which are considered to be stimulants.
Estradiol Overview
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Vaginal estrogen is used to treat vaginal dryness, itching, and burning; painful or difficult urination; and sudden need to urinate immediately in women who are experiencing or have experienced menopause (change of life; the end of monthly menstrual periods). Femring® brand vaginal ring is also used to treat hot flushes ('hot flashes'; sudden strong feelings of heat and sweating) in women who are experiencing menopause. Premarin® brand vaginal cream is also used to treat kraurosis vulvae (a condition that may cause vaginal dryness and discomfort in women or girls of any age). Imvexxy® brand vaginal inserts are used for the treatment of dyspareunia (difficult or painful sexual intercourse) in menopausal women. Vaginal estrogen is in a class of medications called hormones. It works by replacing estrogen that is normally produced by the body.
Acacia Rigidula - More Interactions
Acacia Rigidula interacts with 770 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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