American Mistletoe - Yervoy (Ipilimumab) Interaction
Herbal: American Mistletoe
Also Known As: Phoradendron leucarpum, Eastern Mistletoe
Drug: Ipilimumab
Brand names:
Yervoy
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 02, 2024
Interaction Details
There were no interactions found between Ipilimumab and American Mistletoe. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
American Mistletoe Overview
American mistletoe, scientifically known as Phoradendron leucarpum, is a parasitic plant found in the eastern United States and Mexico. It grows on hardwood trees like oaks and hickories. Although it has been used in traditional Native American medicine, there isn't strong scientific evidence for its effectiveness.
American mistletoe contains phoratoxin, a compound that can be toxic. This toxin induces smooth muscle contraction, leading to increased uterine and intestinal motility, which can result in gastrointestinal symptoms. Additionally, it can cause vasoconstriction, leading to changes in blood pressure and heart rate, similar to the effects of cardiotoxins found in cobra venom.
Most case reports documenting ingestion suggest that eating up to 20 berries or 5 leaves is unlikely to cause serious harm, but there are reports of fatalities from cardiovascular collapse after drinking tea made from an unspecified amount of berries.
It's important to note that American mistletoe is different from European mistletoe, which is more commonly used in dietary supplements.
Ipilimumab Overview
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Ipilimumab injection is used alone or in combination with nivolumab (Opdivo) to treat certain types of melanoma (a type of skin cancer) that that has spread to other parts of the body or cannot be treated with surgery. It is also used alone to prevent melanoma from returning after surgery. Ipilimumab injection is also used in combination with nivolumab to treat certain types of renal cell cancer (a type of cancer that begins in the cells of the kidneys), colorectal cancer (cancer that begins in the large intestine), hepatocellular cancer (a type of liver cancer), esophageal cancer (cancer of the tube that connects your throat to your stomach), and malignant pleural mesothelioma (a type of cancer that affects the inside lining of the lungs and chest cavity). It is also used in combination with nivolumab and other chemotherapy medications to treat a certain type of lung cancer (non-small cell lung cancer, NSCLC). Ipilimumab injection is in a class of medications called monoclonal antibodies. It works by helping the body to slow or stop the growth of cancer cells.
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Your doctor will review your specific type of cancer and past treatment history and other available treatments to determine if ipilimumab is right for you.
American Mistletoe - More Interactions
American Mistletoe interacts with 187 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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