Andrographis - Tysabri (Natalizumab) Interaction
Herbal: Andrographis
Also Known As: Andrographis paniculata, Bhunimba, Bidara, Carmantina, Carmantine, Chiretta, Chirette Verte, Chirreta, Chuan Xin Lian, Creat, Gubak, Indian Echinacea, Justicie, Kalmegh, Kalamegha, Kariyat, King of Bitters, Kirta, Mahalita, Nabin Chanvandi, Nemone Chinensi, Poogiphalam
Drug: Natalizumab
Brand names:
Tysabri
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Natalizumab is classified as belonging to the following category: Immunosuppressants
Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9.
Andrographis Overview
Andrographis is a type of plant native to Asia and is commonly used in traditional medicine. It is a member of the Acanthaceae family and is sometimes referred to as "Indian echinacea." Andrographis is believed to have a number of potential health benefits and is often used to treat infections, such as the common cold and flu, as well as other health conditions.
Studies have shown that Andrographis contains a number of compounds, and dietary supplements are often standardized with a specific amount of one in particular, andrographolide.
Natalizumab Overview
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Natalizumab is used to prevent episodes of symptoms and slow the worsening of disability in adults who have relapsing forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control), including:
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clinically isolated syndrome (CIS; first nerve symptom episode that lasts at least 24 hours),
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relapsing-remitting disease (course of disease where symptoms flare up from time to time),
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active secondary progressive disease (later stage of disease with continuous worsening of symptoms.)
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Natalizumab is also used to treat and prevent episodes of symptoms in adults who have Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) who have not been helped by other medications or who cannot take other medications. Natalizumab is in a class of medications called monoclonal antibodies. It works by stopping certain cells of the immune system from reaching the brain and spinal cord or digestive tract and causing damage.
Andrographis - More Interactions
Andrographis interacts with 393 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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