Androstenediol - Diethylstilbestrol, Methyltestosterone Interaction
Herbal: Androstenediol
Drug: Diethylstilbestrol, Methyltestosterone
Brand names:
Tylosterone
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Diethylstilbestrol, Methyltestosterone is classified as belonging to the following category: Testosterone
Androstenediol is a precursor to testosterone and can increase levels of testosterone. There is some concern that taking androstenediol with testosterone might increase therapeutic and adverse effects of testosterone. However, androstenediol is converted to testosterone in low testosterone environments. Patients taking supplemental testosterone do not have low testosterone levels. Therefore, androstenediol might not be converted to testosterone in these patients. It is unclear how this might alter the effects and side effects of androstenediol. Until more is known, use with caution or avoid using with testosterone-containing drugs. Some of these drugs include Androderm Transdermal, AndroGel, Depo-Testosterone, Testex, Testoderm, and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
- Brown GA, Martini ER, Roberts BS, et al. Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 2002;92:142-6.
Androstenediol Overview
Androstenediol is a naturally occurring steroid hormone in the body that serves as a precursor to testosterone and other androgens. It is classified as a prohormone and a weak anabolic steroid. Androstenediol is sometimes used in dietary supplements for its purported effects on increasing testosterone levels and enhancing athletic performance, although its effectiveness and safety for these purposes are not well-established. In the United States, androstenediol is listed as a Schedule III controlled substance, meaning it has a potential for abuse and dependence. It is also banned by organizations like the National Collegiate Athletic Association (NCAA) and the World Anti-Doping Agency (WADA) for use in sports competitions.
Androstenediol - More Interactions
Androstenediol interacts with 47 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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