Interaction Details

Testosterone Enanthate is classified as belonging to the following category: Testosterone

Androstenediol is a precursor to testosterone and can increase levels of testosterone. There is some concern that taking androstenediol with testosterone might increase therapeutic and adverse effects of testosterone. However, androstenediol is converted to testosterone in low testosterone environments. Patients taking supplemental testosterone do not have low testosterone levels. Therefore, androstenediol might not be converted to testosterone in these patients. It is unclear how this might alter the effects and side effects of androstenediol. Until more is known, use with caution or avoid using with testosterone-containing drugs. Some of these drugs include Androderm Transdermal, AndroGel, Depo-Testosterone, Testex, Testoderm, and others.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
  • Brown GA, Martini ER, Roberts BS, et al. Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 2002;92:142-6.

Androstenediol Overview

Androstenediol Androstenediol is a naturally occurring steroid hormone in the body that serves as a precursor to testosterone and other androgens. It is classified as a prohormone and a weak anabolic steroid. Androstenediol is sometimes used in dietary supplements for its purported effects on increasing testosterone levels and enhancing athletic performance, although its effectiveness and safety for these purposes are not well-established. In the United States, androstenediol is listed as a Schedule III controlled substance, meaning it has a potential for abuse and dependence. It is also banned by organizations like the National Collegiate Athletic Association (NCAA) and the World Anti-Doping Agency (WADA) for use in sports competitions.
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Testosterone Enanthate Overview

  • Testosterone cypionate (Depo-Testosterone), testosterone enanthate (Xyosted, available generically), testosterone undecanoate (Aveed), and testosterone pellet (Testopel) are forms of testosterone injection used to treat symptoms of low testosterone in men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). Testosterone is used only for men with low testosterone levels caused by certain medical conditions, including disorders of the testicles, pituitary gland (a small gland in the brain), or hypothalamus (a part of the brain) that cause hypogonadism. Your doctor will order certain lab tests to check your testosterone levels to see if they are low before you begin to use testosterone injection. Testosterone enanthate (available generically) and testosterone pellet (Testopel) are also used to stimulate puberty in males with delayed puberty. Testosterone enanthate (available generically) injection may be used in certain women with a type of breast cancer called mammary cancer that has spread to other parts of the body. Testosterone should not be used to treat the symptoms of low testosterone in men who have low testosterone due to aging ('age related hypogonadism'). Testosterone is in a class of medications called androgenic hormones. Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. Testosterone injection works by supplying synthetic testosterone to replace the testosterone that is normally produced naturally in the body. When used to treat breast cancer, testosterone works by stopping the release of estrogen.

See More Information Regarding Testosterone Injection

Androstenediol - More Interactions

Androstenediol interacts with 47 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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