Angostura - Neurontin (Gabapentin) Interaction
Herbal: Angostura
Also Known As: Angostura trifoliata, Angusture, Angusture Vraie, Angustura, Carony Bark, Chuspa, Cusparia, Cusparia Bark, True Angostura
Drug: Gabapentin
Brand names:
Neurontin, Gralise
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 26, 2024
Interaction Details
There were no interactions found between Gabapentin and Angostura. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Angostura Overview
Angostura is a shrub-like tree native to Venezuela and other tropical areas of South America, growing up to 4-5 meters high with smooth, gray bark. The bark is used in medicine, particularly for its properties in treating fever, diarrhea, preventing recurrence of malaria, and as an antispasmodic. When taken in large doses, angostura can have cathartic and emetic effects. In foods, angostura is used in alcoholic beverages, although angostura bitters no longer contain angostura, but gentian and other bitters. The bark contains angostura bitters 1 and 2, alkaloids like cuspareine, cusparine, and galipine, as well as a volatile oil. Galipinine and other alkaloids in angostura have shown antimalarial effects in vitro, supporting its traditional use for malaria prevention. The alkaloids cusparine and galipine also exhibit antispasmodic effects in vitro. Angostura is considered Generally Recognized As Safe (GRAS) for use in foods in the United States.
Gabapentin Overview
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Gabapentin capsules, tablets, and oral solution are used along with other medications to help control certain types of seizures in people who have epilepsy. Gabapentin capsules, tablets, and oral solution are also used to relieve the pain of postherpetic neuralgia (PHN; the burning, stabbing pain or aches that may last for months or years after an attack of shingles). Gabapentin extended-release tablets (Horizant) are used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Gabapentin is in a class of medications called anticonvulsants. Gabapentin treats seizures by decreasing abnormal excitement in the brain. Gabapentin relieves the pain of PHN by changing the way the body senses pain. It is not known exactly how gabapentin works to treat restless legs syndrome.
Angostura - More Interactions
Angostura interacts with 0 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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