Angostura - Leukine (Sargramostim) Interaction
Herbal: Angostura
Also Known As: Angostura trifoliata, Angusture, Angusture Vraie, Angustura, Carony Bark, Chuspa, Cusparia, Cusparia Bark, True Angostura
Drug: Sargramostim
Brand names:
Leukine
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Sargramostim and Angostura. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Angostura Overview
Angostura is a shrub-like tree native to Venezuela and other tropical areas of South America, growing up to 4-5 meters high with smooth, gray bark. The bark is used in medicine, particularly for its properties in treating fever, diarrhea, preventing recurrence of malaria, and as an antispasmodic. When taken in large doses, angostura can have cathartic and emetic effects. In foods, angostura is used in alcoholic beverages, although angostura bitters no longer contain angostura, but gentian and other bitters. The bark contains angostura bitters 1 and 2, alkaloids like cuspareine, cusparine, and galipine, as well as a volatile oil. Galipinine and other alkaloids in angostura have shown antimalarial effects in vitro, supporting its traditional use for malaria prevention. The alkaloids cusparine and galipine also exhibit antispasmodic effects in vitro. Angostura is considered Generally Recognized As Safe (GRAS) for use in foods in the United States.
Sargramostim Overview
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Sargramostin is used to decrease the chance of infection in people who have acute myelogenous leukemia (AML; a type of cancer of the white blood cells) and are receiving chemotherapy medications that may decrease the number of neutrophils (a type of blood cell needed to fight infection). Sargramostin is also used in people who are undergoing blood stem cell transplants, in people who are undergoing bone marrow transplants, and to prepare the blood for leukapheresis (a treatment in which certain blood cells are removed from the body and then returned to the body following chemotherapy). Sargramostim is also used in people who have not responded after receiving a blood marrow transplant. Sargramostin is in a class of medications called colony-stimulating factors. It works by helping the body make more neutrophils and certain other blood cells.
Angostura - More Interactions
Angostura interacts with 0 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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