Arimistane - Letrozole, Ribociclib Succinate Interaction
Herbal: Arimistane
Also Known As: Estrovade
Drug: Letrozole, Ribociclib Succinate
Brand names:
Kisqali Femara Co-Pack
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 17, 2024
Interaction Details
Letrozole, Ribociclib Succinate is classified as belonging to the following category: Aromatase Inhibitors
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors. This interaction could potentially increase the risk of side effects associated with low estrogen levels or from additive side effects, such as an increased risk of liver toxicity. It is recommended to consult with a healthcare provider before combining Arimistane with other aromatase inhibitors to assess the potential risks and benefits.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Arimistane Overview
Arimistane is a steroidal aromatase inhibitor, designed to increase testosterone levels by blocking the conversion of testosterone to estrogen. It is commonly used alongside anabolic steroids to mitigate side effects such as gynecomastia, which can occur when excess testosterone is converted to estrogen. Regulatory agencies, including the U.S. FDA, warn against using dietary supplements containing aromatase inhibitors, citing potential adverse effects such as aggressive behavior, adrenal insufficiency, decreased bone maturation and growth, decreased sperm production, infertility, kidney failure, and liver dysfunction.
Arimistane - More Interactions
Arimistane interacts with 4 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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