Interaction Details

There were no interactions found between Bismuth Subsalicylate (OTC drug) and Ashwagandha. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.


Still looking for more information about combining Bismuth Subsalicylate (OTC drug) and Ashwagandha? Ask Dr. Brian Staiger about it by contacting him directly.

Pharmacist Analysis

The use of ashwagandha may result in potential interactions with certain classes of medication due to its known effects. However, these interactions are generally considered to be of minimal clinical significance.

Nevertheless, it is recommended to exercise caution when using ashwagandha in conjunction with the following classes of drugs:

  • Antidiabetes 
  • Antihypertensives
  • Benzodiazepines
  • CNS Depressants
  • Immunosuppressant
  • Thyroid Hormones

Although ashwagandha can typically be used safely in combination with these drug classes, it is crucial to inform your healthcare provider of all medications and supplements you are taking to ensure proper monitoring. Based on available information, ashwagandha does not appear to cause any adverse interactions with the specific drug mentioned in this inquiry.

Ashwagandha With Pepto-Bismol

Ashwagandha With Pepto Bottle

There is currently no known interaction between ashwagandha and Pepto-Bismol.

However, it is important to note that Pepto-Bismol can interact with other medications and supplements. For example, Pepto-Bismol can decrease the absorption of antibiotics, such as tetracycline and doxycycline, and it can interact with blood thinners, such as warfarin.

Additionally, Pepto-Bismol contains salicylates, which are similar to aspirin and can increase the risk of bleeding when taken with other blood-thinning medications or supplements, such as garlic, ginkgo, and vitamin E.

While there is no known interaction with ashwagandha, it is important to consult with a healthcare professional before taking Pepto-Bismol or any other medication or supplement.

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Ashwagandha Overview

Ashwagandha Ashwagandha, also known as Withania somnifera, is a herb commonly used in Ayurvedic medicine. It is native to India, and is used to treat a variety of conditions, including stress, anxiety, and insomnia. Some studies have also suggested that ashwagandha may have potential health benefits for conditions such as heart disease, diabetes, and cancer. However, more research is needed. Ashwagandha is often referred to as an adaptogenic herb, which is theorized to help the body to adapt to stress.
See More Information Regarding Ashwagandha

Bismuth Subsalicylate (OTC drug) Overview

  • Bismuth subsalicylate is used to treat diarrhea, heartburn, and upset stomach in adults and children 12 years of age and older. Bismuth subsalicylate is in a class of medications called antidiarrheal agents. It works by decreasing the flow of fluids and electrolytes into the bowel, reduces inflammation within the intestine, and may kill the organisms that can cause diarrhea.

See More Information Regarding Bismuth Subsalicylate

Ashwagandha - More Interactions

Ashwagandha interacts with 623 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Ask A Pharmacist About Your Herbal Questions!

Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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