Asparagus - Imbruvica (Ibrutinib) Interaction
Herbal: Asparagus
Also Known As: Asparagus officinalis, Asparagi Rhizoma Root, Asperge, Asperge Comestible, Asperge Commune, Asperge Officinale, Asperges, Espárrago, Garden Asparagus, Spargelkraut, Spargelwurzelstock, Sparrow Grass
Drug: Ibrutinib
Brand names:
Imbruvica
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Ibrutinib and Asparagus. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Asparagus Overview
Asparagus officinalis, commonly known as asparagus, is a perennial plant native to central and southern Europe, the Middle East, western Siberia, and northern Africa. It grows to heights of 30-150 cm and is widely cultivated as a vegetable. Asparagus has been part of the human diet for over 2000 years and possibly much longer. Its shoots or "spears," rhizome, root, and juice are used for food and medicine. Asparagus is a good source of fiber, folic acid, vitamin C, vitamin E, and vitamin B6, as well as minerals like copper, iron, zinc, manganese, calcium, magnesium, sodium, potassium, and phosphorous. It contains flavonoids, hydroxycinnamic acids, oligosaccharides, amino acids, carotenoids, sulfur compounds, steroidal saponins, sterols, and fructans.
After ingestion, asparagus produces a distinctive odor in urine due to volatile organic components like asparagusic acid. Asparagus extracts have shown various effects in studies, including anti-allergy, anti-cancer, anti-inflammatory, antimicrobial, antiviral, antioxidant, cholesterol-lowering, diuretic, hepatic, hypotensive, immunostimulatory, and weight-modifying effects. However, some of its constituents, particularly saponins, can irritate mucous membranes and be cytotoxic.
Ibrutinib Overview
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Ibrutinib is used:
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to treat people with mantle cell lymphoma (MCL; a fast-growing cancer that begins in the cells of the immune system) who have already been treated with at least one other chemotherapy medication,
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to treat people with chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells) and small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes),
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to treat people with Waldenstrom's macroglobulinemia (WM; a slow-growing cancer that begins in certain white blood cells in your bone marrow),
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to treat people with marginal zone lymphoma (MZL; a slow growing cancer that begins in a type of white blood cells that normally fights infection) who have already been treated with a certain type of chemotherapy medication,
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and to treat people with chronic graft vs host disease (cGVHD; a complication of hematopoietic stem-cell transplant [HSCT; a procedure that replaces diseased bone marrow with healthy bone marrow] that may start a while after the transplant and last for a long time) after being treated unsuccessfully with 1 or more medications.
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Ibrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.
Asparagus - More Interactions
Asparagus interacts with 76 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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