Atractylodes - Faslodex (Fulvestrant) Interaction
Herbal: Atractylodes
Also Known As: Atractylodes lancea, AMK, ATR, Atractylenolide, Bai Zhu, Byaki-Jutsu, Cang Zhu, Chang Zhe, Jutsu, Khod Kha Mao, Paekch'ul, So-Jutsu
Drug: Fulvestrant
Brand names:
Faslodex
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 23, 2024
Interaction Details
There were no interactions found between Fulvestrant and Atractylodes. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Atractylodes Overview
Atractylodes is a genus of flowering plants native to eastern Asia, with its roots being used in traditional Chinese medicine (TCM), traditional Japanese medicine (Kampo), and traditional Thai medicine. It is found in formulations like ninjin-yoei-to and shenling baizhu san. Pharmacokinetic studies show that atractylodin, a major bioactive compound, is absorbed rapidly after oral administration, with peak plasma concentrations reached within 0.5-2 hours. The root contains sesquiterpenoids, sterols, and essential oils, with constituents like atractylenolides and atractylon. These compounds contribute to various purported pharmacological effects, including anti-cancer, anti-inflammatory, anti-viral, and gastrointestinal effects, but more research is needed for a better understanding of its overall effectiveness in these areas.
Fulvestrant Overview
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Fulvestrant injection is used alone or in combination with ribociclib (Kisqali®) to treat a certain type of hormone receptor positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) or breast cancer has spread to other parts of the body in women who have experienced menopause (change of life; end of monthly menstrual periods) and have not previously been treated with an anti-estrogen medication such as tamoxifen (Nolvadex). Fulvestrant injection is also used alone or in combination with ribociclib (Kisqali®) to treat hormone receptor positive, advanced breast cancer or breast cancer that has spread to other parts of the body in women who have experienced menopause and whose breast cancer has worsened after they were treated with an anti-estrogen medication such as tamoxifen. Fulvestrant injection is also used in combination with palbociclib (Ibrance®) or abemaciclib (Verzenio®) to treat hormone receptor positive, advanced breast cancer in women whose breast cancer has spread to other parts of the body and has worsened after they were treated with anti-estrogen medication such as tamoxifen. Fulvestrant is in a class of medications called estrogen receptor antagonists. It works by blocking the action of estrogen on cancer cells. This can slow or stop the growth of some breast tumors that need estrogen to grow.
Atractylodes - More Interactions
Atractylodes interacts with 775 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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