Betel Nut - Doxorubicin Interaction Details

Interaction Details

Doxorubicin is classified as belonging to the following category: Doxorubicin (Adriamycin, Others)

In one case report, a woman treated with doxorubicin for breast cancer developed severe oral, genital, and anal mucositis that was considered to be probably related to betel nut use. It was hypothesized that chewing betel nut increased the risk of mucositis related to doxorubicin. Theoretically, concomitant use of betel nut with doxorubicin might increase the risk for adverse effects. Until more is known, tell patients treated with doxorubicin to avoid betel nut.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

Epstein, R. J., Leung, T. W., and Cheung, P. S. Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy. Cancer Chemother.Pharmacol 2006;58(6):835-837.

Doxorubicin Overview

Doxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (cancer that begins in the cells of the immune system); and certain types of leukemia (cancer of the white blood cells), including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML, ANLL). Doxorubicin is also used alone and in combination with other medications to treat certain types of thyroid cancer and certain types of soft tissue or bone sarcomas (cancer that forms in muscles and bones). It is also used to treat neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children) and Wilms' tumor (a type of kidney cancer that occurs in children). Doxorubicin is in a class of medications called anthracyclines. It works by slowing or stopping the growth of cancer cells in your body.

See More Information Regarding Doxorubicin

Betel Nut - More Interactions

Betel Nut interacts with 226 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.