Black Hellebore - Harvoni (Ledipasvir, Sofosbuvir) Interaction
Herbal: Black Hellebore
Also Known As: Helleborus niger, Christe Herbe, Christmas Rose, Christmas Rose Plant, Eléboro Negro, Ellébore Noir, Hellébore Noir, Herbe aux Fous, Melampode, Rose de Carême, Rose de Noël, Rose Noire
Drug: Ledipasvir, Sofosbuvir
Brand names:
Harvoni
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Ledipasvir, Sofosbuvir and Black Hellebore. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Black Hellebore Overview
Black Hellebore (Helleborus niger), also known as Christmas Rose, is a perennial flowering plant native to Europe. Despite its toxic nature, it's admired for its striking white or pale pink flowers that often bloom in winter, hence the name "Christmas Rose." However, its ingestion can be poisonous and has been used historically in herbal medicine with caution due to its potent compounds.
Ledipasvir, Sofosbuvir Overview
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The combination of ledipasvir and sofosbuvir is used alone or in combination with ribavirin (Copegus, Rebetol, Ribasphere, others) to treat certain types of chronic hepatitis C (an ongoing viral infection that damages the liver) in adults and children 3 years of age and older. Sofosbuvir is in a class of antiviral medications called nucleotide polymerase inhibitors. It works by decreasing the amount of hepatitis C virus (HCV) in the body. Ledipasvir is in a class of antiviral medications called HCV NS5A inhibitors. It works by stopping the virus that causes hepatitis C from spreading inside the body.
Black Hellebore - More Interactions
Black Hellebore interacts with 133 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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