Boswellia Serrata - Opdivo (Nivolumab) Interaction

Interaction Details

Pharmacist Analysis

No interaction has been noted between Boswellia and the drug in question on this interaction check.

In terms of other interactions, Boswellia serrata has been shown in laboratory studies to mildly inhibit several enzymes involved in drug metabolism, including CYP1A2, CYP2C19, CYP2C9, CYP2D6, and CYP3A4. This inhibition may increase the levels of drugs metabolized by these enzymes, potentially leading to adverse effects.

However, it is important to note that this inhibition has only been seen in a lab setting, and has not been reported in humans. Whether or not Boswellia supplements have clinically significant drug interactions due to the effects on the above enzymes isn't well known. In most cases, it appears unlikely that these interactions would be clinically significant as there is a lack of reports of problems being caused in humans.

In addition, Boswellia serrata may interact with immunosuppressive drugs. 

Studies show that Boswellia may help reduce the activity of some cells involved in autoimmune diseases. This could lead to a decrease in the production of antibodies and certain immune cells. However, other studies have found that certain components of Boswellia serrata may actually stimulate the immune system in certain situations. More research is needed to better understand the effect of Boswellia on immunosuppressive drugs.

Nivolumab Overview

• Nivolumab injection is used alone or in combination with ipilimumab (Yervoy) to treat certain types of melanoma (a type of skin cancer) in adults and children 12 years of age or older that has spread to other parts of the body or cannot be removed by surgery. It is also used alone to prevent melanoma from returning after surgery. Nivolumab injection is also used in alone or in combination with ipilimumab and/or other chemotherapy medications to treat certain types of lung cancer (non-small cell lung cancer; NSCLC), renal cell cancer (a type of cancer that begins in the cells of the kidneys), Hodgkin's lymphoma (Hodgkin's disease), head and neck cancer, urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract), colorectal cancer (cancer that begins in the large intestine), hepatocellular carcinoma (HCC; a type of liver cancer), esophageal cancer (cancer of the tube that connects your throat to your stomach), gastric cancer (cancer of the stomach) or gastroesophageal junction cancer (cancer located in the area where the stomach meets the esophagus), and malignant pleural mesothelioma (a type of cancer that affects the inside lining of the lungs and chest cavity). Nivolumab is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.

• Your doctor will review your specific type of cancer and past treatment history and other available treatments to determine if nivolumab is right for you.

Boswellia Serrata - More Interactions

Boswellia Serrata interacts with 920 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.