Calamus - Xarelto (Rivaroxaban) Interaction
Herbal: Calamus
Also Known As: Acorus calamus, Acore Calame, Acore Odorant, Acore Olorant, Acore Roseau, Acorus Roseau, Aruna, Bach, Bajai, Baje, Belle-Angélique, Bhutanashini, Cálamo, Calamo Aromatic, Calamus Root, Cinnamon Sedge, Flag Root, Flagroot, Gladdon, Golomi, Grass-Leaf Sweetflag, Grass Myrtle, Ka
Drug: Rivaroxaban
Brand names:
Xarelto
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 26, 2024
Interaction Details
Rivaroxaban is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
In vitro research suggests that calamus inhibits cytochrome P450 3A4 (CYP3A4). Theoretically, use of calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effects.
Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Pandit S, Mukherjee PK, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of a-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 2011;82(3):369-74.
Calamus Overview
Calamus is a grass-like plant commonly mostly commonly found in Eastern Europe in swamps or along the banks of waterways. Calamus has traditionally been used in both Ayurdevic and Chinese medicine for a number of ailments, including digestive disorders including colic, ulcers, gastritis, flatulence, diarrhea, intestinal infections, dyspepsia, and anorexia. It is also used to induce vomiting, induce sweating, improve memory and for the treatment of inflammatory disorders. The FDA does not allow calamus in food due research showing it has carcinogenic effects, likely due to the beta-asarone content, which can vary heavily depending on the species.
Rivaroxaban Overview
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Rivaroxaban is used to treat deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung) in adults. Rivaroxaban is also used to prevent DVT and PE from happening again after initial treatment is completed in adults. It is also used to help prevent strokes or serious blood clots in adults who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) that is not caused by heart valve disease. Rivaroxaban is also used to prevent DVT and PE in adults who are having hip replacement or knee replacement surgery or in people who are hospitalized for serious illnesses and are at risk of developing a clot due to decreased ability to move around or other risk factors. It is also used along with aspirin to lower the risk of a heart attack, stroke, or death in adults with coronary artery disease (narrowing of the blood vessels that supply blood to the heart) or peripheral arterial disease (poor circulation in the blood vessels that supply blood to the arms and legs). Rivaroxaban is also used to treat and prevent DVT and PE from happening again in children and certain infants who have received at least 5 days of initial anticoagulation (blood thinner) treatment. It is also used to prevent DVT and PE after heart surgery in children 2 years of age or older who have congenital heart disease (abnormality in the heart that develops before birth). Rivaroxaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.
Calamus - More Interactions
Calamus interacts with 1091 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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