Cola Nut - Phexxi (Lactic Acid, Citric Acid, Potassium Bitartrate) Interaction
Herbal: Cola Nut
Also Known As: Cola acuminata, Bissey Nut, Bissy Nut, Bitter Kola, Guru Nut, Gworo, Kola Nut, Kolatier, Noix de Cola, Noix de Kola, Noix du Soudan, Nuez de Cola, Soudan Coffee
Drug: Lactic Acid, Citric Acid, Potassium Bitartrate
Brand names:
Phexxi
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Lactic Acid, Citric Acid, Potassium Bitartrate is classified as belonging to the following category: Contraceptive Drugs
Theoretically, contraceptive drugs might increase the effects and adverse effects of the caffeine in cola nut.
Cola nut contains caffeine. Oral contraceptives can decrease the rate of caffeine clearance by 40% to 65%.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40.
- Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985;28:425-8.
Cola Nut Overview
Cola nut (Cola acuminata) is a plant native to West Africa and a member of the Malvaceae family. The plant has dark green leaves and produces clusters of small, white flowers. The seeds of the cola nut plant have been used in traditional medicine for their purported effects, such as stimulating the central nervous system, improving physical performance, and increasing energy and alertness. It is sometimes added to energy drinks, weight loss supplements, and other products. Caffeine is one of the compounds found in Cola nut seeds.
Lactic Acid, Citric Acid, Potassium Bitartrate Overview
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The combination of lactic acid, citric acid, and potassium bitartrate is used to prevent pregnancy when used just before vaginal sex in women who can become pregnant. It does not prevent pregnancy when used after vaginal sex. The combination of lactic acid, citric acid, and potassium bitartrate is in a class of medications called non-hormonal contraceptives. It works by lowering the pH of the vagina and reducing sperm motility. Lactic acid, citric acid, and potassium bitartrate may prevent pregnancy, but this medication will not prevent the spread of human immunodeficiency virus (HIV, the virus that causes acquired immunodeficiency syndrome [AIDS]) and other sexually transmitted diseases.
Cola Nut - More Interactions
Cola Nut interacts with 643 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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