Interaction Details

There were no interactions found between Ivabradine and Comfrey. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.


Still looking for more information about combining Ivabradine and Comfrey? Ask Dr. Brian Staiger about it by contacting him directly.

Comfrey Overview

Comfrey Comfrey (Symphytum officinale) is an herbaceous plant that belongs to the borage family (Boraginaceae). It is native to Europe and Asia and is known for its hairy, green leaves and small, purple, bell-shaped flowers. Comfrey has a long history of use in traditional medicine and contains a number of active compounds, including allantoin, which is believed to have anti-inflammatory and healing properties. It has been traditionally used to treat a variety of ailments, including wounds, fractures, and skin conditions. In addition, comfrey is believed to have astringent and expectorant effects, and has been used to treat respiratory disorders and coughs. It is important to note that comfrey may cause liver damage if taken in large amounts (orally) or over a long period of time and should be used with caution. The FDA has recommended removal of oral comfrey products from the market due to potential for liver toxicity although it is currently still available. It is most often seen in topical forms (e.g., as an ointment).
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Ivabradine Overview

  • Ivabradine is used to treat certain adults with heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body) to decrease the risk that their condition will worsen and need to be treated in a hospital. It is also used to treat a certain type of heart failure in children 6 months of age and older due to cardiomyopathy (a condition in which the heart muscle becomes weakened and enlarged). Ivabradine is in a class of medications called hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers. It works by slowing the heart rate so the heart can pump more blood through the body each time it beats.

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Comfrey - More Interactions

Comfrey interacts with 409 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

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Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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