Dimethylsulfoxide (dmso) - Estradiol Interaction
Herbal: Dimethylsulfoxide (dmso)
Also Known As: Dimethyl Sulfoxide, Dimethyl Sulphoxide, Dimethylis Sulfoxidum
Drug: Estradiol
Brand names:
Estrace, Gynodiol, Vagifem, Estring, Vivelle, Estraderm, Divigel, Evamist, Elestrin, Minivelle, Imvexxy, Oestrogel
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Estradiol is classified as belonging to the following category: Topical Drugs
Topical DMSO might increase the effects and adverse effects of topical drugs.
Evidence from animal studies and limited human studies suggests that DMSO may potentiate the action of numerous topical medications by increasing their absorption through the skin. This increase in absorption seems to depend on the concentration of DMSO and the molecular weight of the medication.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Jacob SW, Herschler R. Pharmacology of DMSO. Cryobiology 1986;23:14-27.
- Capriotti K, Capriotti JA. Dimethyl sulfoxide: history, chemistry, and clinical utility in dermatology. J Clin Aesthet Dermatol. 2012;5(9):24-6.
- DOMOSO SOLUTION (90% Dimethyl Sulfoxide). Fort Dodge Animal Health, Fort Dodge, Iowa. Avaliable at: https://www.zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/domoso_solution_pi.pdf. Accessed 8/3/2020.
Dimethylsulfoxide (dmso) Overview
Dimethylsulfoxide (DMSO) is a colorless, odorless liquid that has a number of industrial and medical uses.
In a medicinal sense, DMSO is most commonly used as a topical pain reliever and anti-inflammatory agent. It is applied to the skin as a cream or gel, and is sometimes used to treat conditions such as muscle strains, sprains, and arthritis. DMSO is also an FDA-approved treatment for interstitial cystitis, a condition that causes bladder pain and frequent urination, when given via intravesical instillation (administration directly into the bladder).
DMSO is often added to topical preparations to increase the skin penetration of some medications.
Estradiol Overview
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Vaginal estrogen is used to treat vaginal dryness, itching, and burning; painful or difficult urination; and sudden need to urinate immediately in women who are experiencing or have experienced menopause (change of life; the end of monthly menstrual periods). Femring® brand vaginal ring is also used to treat hot flushes ('hot flashes'; sudden strong feelings of heat and sweating) in women who are experiencing menopause. Premarin® brand vaginal cream is also used to treat kraurosis vulvae (a condition that may cause vaginal dryness and discomfort in women or girls of any age). Imvexxy® brand vaginal inserts are used for the treatment of dyspareunia (difficult or painful sexual intercourse) in menopausal women. Vaginal estrogen is in a class of medications called hormones. It works by replacing estrogen that is normally produced by the body.
Dimethylsulfoxide (dmso) - More Interactions
Dimethylsulfoxide (dmso) interacts with 323 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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