Docosahexaenoic Acid (dha) - Zetia (Ezetimibe) Interaction
Herbal: Docosahexaenoic Acid (dha)
Also Known As: ADH, DHA, Fish Oil Fatty Acid, N-3 Fatty Acid, Neuromins, Omega 3, Omega 3 Fatty Acids, Omega-3, Omega-3 Fatty Acids, W-3 Fatty Acid
Drug: Ezetimibe
Brand names:
Zetia
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Ezetimibe and Docosahexaenoic Acid (dha). This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Docosahexaenoic Acid (dha) Overview
DHA (docosahexaenoic acid) is an omega-3 fatty acid that is important for the proper functioning of the nervous system and eyes.
DHA can be found in a variety of foods and in abundance in many different types of fatty fish, such as salmon and mackerel. It is a popular dietary supplement, consistently among the most utilized.
There is some evidence to suggest that DHA may have a number of potential health benefits, including improving cognitive function and reducing the risk of age-related cognitive decline. It has also been shown to be important for fetal and infant brain development and is a common component in prenatal vitamins.
DHA is often combined with EPA (eicosapentaenoic acid) in dietary supplements and both are found together in most fish-sourced ones. One main difference between DHA and EPA is their structure. DHA is a long-chain fatty acid, while EPA is a medium-chain fatty acid. This difference in structure may affect how they are utilized in the body and their potential health benefits. For example, DHA is more highly concentrated in the brain and is believed to be important for brain and eye health, while EPA is more highly concentrated in the heart and may be helpful in reducing inflammation and improving cardiovascular health.
Ezetimibe Overview
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Ezetimibe is used together with lifestyle changes (diet, weight-loss, exercise) to reduce the amount of cholesterol (a fat-like substance) and other fatty substances in the blood. It may be used alone or in combination with an HMG-CoA reductase inhibitor (statin). Ezetimibe is in a class of medications called cholesterol-lowering medications. It works by preventing the absorption of cholesterol in the intestine.
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Buildup of cholesterol and fats along the walls of the blood vessels (a process known as atherosclerosis) decreases blood flow, which decreases the oxygen supply to the heart, brain, and other parts of the body. Lowering blood levels of cholesterol and fats may help reduce this buildup and may decrease your chances of developing heart conditions such as angina (chest pain), strokes, and heart attacks. Results of a clinical study that compared people who took ezetimibe and simvastatin with people who took simvastatin alone found that although the group of people taking ezetimibe and simvastatin had lower amounts of cholesterol in the blood, there was no difference between the two groups in the amount of cholesterol and fat buildup on the insides of the blood vessels in the neck. It is not currently understood why the additional lowering of cholesterol levels in the blood did not lead to a greater decrease in cholesterol and fat buildup along the walls of the blood vessels in people taking ezetimibe and simvastatin. Further studies are underway to compare treatment with ezetimibe and simvastatin to treatment with simvastatin alone to see if there is a difference in the risk of developing heart disease. Talk to your doctor if you have questions about the risks and benefits of treating increased amounts of cholesterol in your blood with ezetimibe and other medications.
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In addition to taking a cholesterol-lowering medication, making certain changes in your daily habits can also lower your blood cholesterol levels. You should eat a diet that is low in saturated fat and cholesterol (see SPECIAL DIETARY); exercise 30 minutes on most, if not all, days; and lose weight if you are overweight.
Docosahexaenoic Acid (dha) - More Interactions
Docosahexaenoic Acid (dha) interacts with 367 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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