Echinacea - Mucinex (Guaifenesin) Interaction
Herbal: Echinacea
Also Known As: American Cone Flower, Black Sampson, Black Susans, Comb Flower, Coneflower, Echinaceawurzel, Hedgehog, Igelkopfwurzel, Indian Head, Kansas Snakeroot
Drug: Guaifenesin
Brand names:
Robitussin, Humibid LA, Amibid LA, Numobid, Muco-Fen 800, Bidex, Organidin, X-pect, Mucinex
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 26, 2024
Interaction Details
There were no interactions found between Guaifenesin and Echinacea. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
While echinacea has been shown to affect the activity of certain CYP enzymes, there is no known interaction between echinacea and guaifenesin. They are considered safe to combine.
This is because guaifenesin is primarily metabolized through a process called hydrolysis in the kidney. The body also metabolizes guaifenesin through other processes, such as oxidation and demethylation. These processes do not involve the CYP enzymes in the liver that can potentially be affected by echinacea.
Guaifenesin is generally considered to have no serious drug interactions due to it primarily being eliminated by the kidneys and its lack of effects on the activity of liver enzymes or transporters that are responsible for the metabolism of other drugs.
- Dr. Brian Staiger, PharmDEchinacea Overview
Echinacea is a type of flowering plant that belongs to the daisy family and is native to cental and eastern North America. It is known for its purple, cone-shaped flowers. In traditional medicine, echinacea has been used to treat a variety of conditions, including colds, flu, and other respiratory infections. It is believed to work by stimulating the immune system and helping the body to fight off infection. Some studies have suggested that echinacea may be effective at reducing the severity and duration of colds and other respiratory infections, but more research is needed to confirm its effectiveness.
Guaifenesin Overview
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Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.
Echinacea - More Interactions
Echinacea interacts with 785 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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