Interaction Details

There were no interactions found between Ciprofloxacin and Elderberry. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.


Still looking for more information about combining Ciprofloxacin and Elderberry? Ask Dr. Brian Staiger about it by contacting him directly.

Pharmacist Analysis

Elderberry has not been shown to affect any liver CYP enzymes to a clinically significant degree. This suggests that the potential for elderberry to interact with medications that are metabolized by these enzymes (e.g., CYP3A4, CYP2D6, etc...) is generally not a concern.

Azithromycin is primarily metabolized by the liver enzyme CYP1A2 and CYP3A4, which elderberry has not been shown to affect in a clinically significant manner.

However, as with any medication or supplement, it is important to talk to your healthcare provider before combining ciprofloxacin with elderberry or any other herbal supplement to ensure that there are no potential interactions or adverse effects.

It is important to note that many elderberry supplements are combined with zinc (for immune support) and zinc administration should be separated from ciprofloxacin to avoid issues with drug absorption.

Elderberry has not been shown to affect any liver CYP enzymes to a clinically significant degree. This suggests that the potential for elderberry to interact with medications that are metabolized by these enzymes (e.g., CYP3A4, CYP2D6, etc...) is generally not a concern.

Azithromycin is primarily metabolized by the liver enzyme CYP1A2 and CYP3A4, which elderberry has not been shown to affect in a clinically significant manner.

However, as with any medication or supplement, it is important to talk to your healthcare provider before combining ciprofloxacin with elderberry or any other herbal supplement to ensure that there are no potential interactions or adverse effects.

It is important to note that many elderberry supplements are combined with zinc (for immune support) and zinc administration should be separated from ciprofloxacin to avoid issues with drug absorption.

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Elderberry Overview

Elderberry Elderberry (Sambucus) is a plant that belongs to the Adoxaceae family. It is native to Europe, Asia, and North America, and has been used for centuries in traditional medicine. The Elderberry plant has distinctive dark purple or black berries, which are often used in different types of food, including jams, jellies, and syrups. In traditional medicine, elderberry is one of the most popular over-the-counter supplements due to its purported immune-stimulating effects and is used to treat colds, flu, and other respiratory infections. Some studies have suggested that elderberry may have antiviral and immune-boosting properties, but more research is needed to confirm these effects. It is important to note that there are several different species of elderberry, including American elder (Sambucus canadensis) and black elder (Sambucus nigra). Black elder is more commonly used in dietary supplements.
See More Information Regarding Elderberry

Ciprofloxacin Overview

  • Ciprofloxacin is used to treat or prevent certain infections caused by bacteria such as pneumonia; gonorrhea (a sexually transmitted disease); typhoid fever (a serious infection that is common in developing countries); infectious diarrhea (infections that cause severe diarrhea); and infections of the skin, bone, joint, abdomen (stomach area), and prostate (male reproductive gland), Ciprofloxacin is also used to treat or prevent plague (a serious infection that may be spread on purpose as part of a bioterror attack) and inhalation anthrax (a serious infection that may be spread by anthrax germs in the air on purpose as part of a bioterror attack). Ciprofloxacin may also be used to treat bronchitis, sinus infections, or urinary tract infections but should not be used for bronchitis and sinus infections, or certain types of urinary tract infections if there are other treatment options. Ciprofloxacin extended-release (long-acting) tablets are used to treat kidney and urinary tract infections; however, some types of urinary tract infections should only be treated with ciprofloxacin extended release tablets if no other treatment options are available. Ciprofloxacin is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections.

  • Antibiotics such as ciprofloxacin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

See More Information Regarding Ciprofloxacin

Elderberry - More Interactions

Elderberry interacts with 112 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Ask A Pharmacist About Your Herbal Questions!

Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

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