Fenugreek - Norvasc (Amlodipine Besylate) Interaction

Interaction Details

Amlodipine Besylate is classified as belonging to the following category: Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

Pharmacist Analysis

Fenugreek may also have an additive effect on blood pressure-lowering medications.

Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together.

It is also important you speak with your doctor before starting fenugreek so you can be appropriately monitored.

Is Fenugreek Safe With Norvasc?

While no studies have specifically evaluated the combined use of fenugreek and Norvasc, there is a theoretical chance that both could cause an additive decrease in blood pressure.

Small animal studies have shown that fenugreek, when added to the beta-blocker metoprolol, can decrease blood pressure.

Human studies have found fenugreek seed supplementation associated with lower systolic blood pressure (but not diastolic).

While the risk of a clinically significant interaction here is low, it is important to monitor your blood pressure while taking fenugreek, especially if you take blood pressure medication.

Amlodipine Besylate Overview

• Amlodipine is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years and older. It is also used to treat certain types of angina (chest pain) and coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Amlodipine is in a class of medications called calcium channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. It controls chest pain by increasing the supply of blood to the heart. If taken regularly, amlodipine controls chest pain, but it does not stop chest pain once it starts. Your doctor may prescribe a different medication to take when you have chest pain.

• High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Fenugreek - More Interactions

Fenugreek interacts with 374 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.