Fenugreek - Wellbutrin XL (Bupropion) Interaction
Herbal: Fenugreek
Also Known As: Trigonella foenum-graecum, Alholva, Bird's Foot, Chandrika, Fenogreco, Fenugrec, Foenugreek, Greek Clover, Greek Hay, Hu Lu Ba, Methi, Methika, Medhika, Senegrain, Senegre, Trigonella, Trigonelle
Drug: Bupropion
Brand names:
Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, Forfivo XL
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 02, 2024
Interaction Details
There were no interactions found between Bupropion and Fenugreek. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Fenugreek is generally considered relatively safe in regard to potential drug interactions.
Nevertheless, interactions are possible between fenugreek and:
- 'Blood-thinning' drugs
- Drugs that lower blood pressure
- Drugs that low blood sugar
Fenugreek contains some components that can prevent blood from clotting. However, there is not enough research to confirm whether the amount of these components present in common fenugreek products can have a clinically significant effect.
Fenugreek may also have an additive effect with blood sugar-lowering medication and blood pressure-lowering medication.
All of these potential interactions are documented individually on our specific drug-herbal interaction pages.
Is Fenugreek Safe With Wellbutrin?
While fenugreek may have additive effects with several different classes of drugs (e.g., blood-pressure medications and anticoagulants), it is not known to affect any liver metabolizing enzymes and is not known to affect how Wellbutrin works.
Similarly, fenugreek is not known to have a risk of causing any additive side effects with Wellbutrin as fenugreek doesn't appear to alter or otherwise change the concentrations of any neurotransmitters in the brain.
Based on the information currently available, there is no indication that Wellbutrin has a clinically significant interaction with fenugreek.
- Dr. Brian Staiger, PharmDFenugreek Overview
Bupropion Overview
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Bupropion (Aplenzin, Wellbutrin, Wellbutrin SR, Wellbutrin XL) is used to treat depression. Bupropion (Aplenzin, Wellbutrin XL) is also used to treat seasonal affective disorder (SAD; episodes of depression that occur at the same time each year [usually in the fall and winter but rarely may occur in the spring or summer months]). Bupropion (Zyban) is used to help people stop smoking. Bupropion is in a class of medications called antidepressants. It works by increasing certain types of activity in the brain.
Fenugreek - More Interactions
Fenugreek interacts with 383 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.