Fermented Milk - Pretomanid Interaction

Interaction Details

Pretomanid is classified as belonging to the following category: Antibiotic Drugs

Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.
Some fermented milk preparations contain live and active organisms, including lactobacillus and bifidobacteria strains. Simultaneously taking antibiotics might kill a significant number of these organisms. Tell patients to separate administration of antibiotics and fermented milk preparations by at least 2 hours.

Interaction Rating

Likelihood of Occurrence

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.

References

• Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
• Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42.

Interaction Details

Pretomanid is classified as belonging to the following category: Immunosuppressants

Theoretically, fermented milk might decrease the effects of immunosuppressants.
Clinical research suggests that fermented milk has immunostimulant effects.

Interaction Rating

Likelihood of Occurrence

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

• Turchet, P., Laurenzano, M., Auboiron, S., and Antoine, J. M. Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study. J Nutr Health Aging 2
• Fukushima, Y., Miyaguchi, S., Yamano, T., Kaburagi, T., Iino, H., Ushida, K., and Sato, K. Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus
• Cobo Sanz, J. M., Mateos, J. A., and Munoz Conejo A. [Effect of Lactobacillus casei on the incidence of infectious conditions in children]. Nutr Hosp 2006;21(4):547-551.
• Tormo Carnicer R., Infante Pina D., Rosello Mayans E., and Bartolome Comas R. [Intake of fermented milk containing Lactobacillus casei DN-114 001 and its effect on gut flora]. An Pediatr (Barc) 2006;65(5):448-453.
• Rio, M. E., Zago Beatriz L., Garcia, H., and Winter, L. [The nutritional status change the effectiveness of a dietary supplement of lactic bacteria on the emerging of respiratory tract diseases in children]. Arch Latinoam Nutr 2002;52(1):29-34.

Pretomanid Overview

• Pretomanid is used along with bedaquiline (Sirturo) and linezolid (Zyvox) to treat multi-drug resistant tuberculosis (MDR-TB; a serious infection that affects the lungs that cannot be treated with other medications) in adults. Pretomanid is in a class of medications called antimycobacterials. It works by killing the bacteria that cause tuberculosis.

Fermented Milk - More Interactions

Fermented Milk interacts with 457 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.