Griffonia Simplicifolia - Epidiolex (Cannabidiol (prescription drug)) Interaction
Herbal: Griffonia Simplicifolia
Also Known As: Bandeiraea simplicifolia
Drug: Cannabidiol (prescription drug)
Brand names:
Epidiolex
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Cannabidiol (prescription drug) is classified as belonging to the following category: Cns Depressants
In clinical trials, 5-HTP, a constituent of Griffonia simplicifolia seed extract, has been associated with drowsiness and somnolence. It is not clear if taking Griffonia simplicifolia in combination with CNS depressants might have the same effects. Theoretically, concomitant use of Griffonia simplicifolia with medications that cause sedation might have additive effects. Some CNS depressants include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Griffonia Simplicifolia Overview
Cannabidiol (prescription drug) Overview
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Cannabidiol is used to control seizures in adults and children 1 year of age and older with Lennox-Gastaut syndrome (a disorder that begins in early childhood and causes seizures, developmental delays, and behavioral issues), Dravet syndrome (a disorder that begins in early childhood and causes seizures and later may lead to developmental delays and changes in eating, balance, and walking), or tuberous sclerosis complex (TSC; a genetic condition that causes tumors to grow in many organs). Cannabidiol is in a class of medications called cannabinoids. It is not known exactly how cannabidiol works to prevent seizure activity.
Griffonia Simplicifolia - More Interactions
Griffonia Simplicifolia interacts with 315 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.