Hibiscus Sabdariffa - Chloroquine, Primaquine Phosphate Interaction
Herbal: Hibiscus Sabdariffa
Also Known As: Hibiscus sabdariffa, Agua de Jamaica, Ambashthaki, Bissap, Erragogu, Flor de Jamaica, Florida cranberry, Gongura, Groseille de Guinée, Guinea Sorrel, Hibisco, Hibiscus Calyx, Jamaica Sorrel, Karkade, Karkadé, Kenaf, Lo Shen, Oseille de Guinée, Oseille Rouge
Drug: Chloroquine, Primaquine Phosphate
Brand names:
Aralen / Primaquine
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Chloroquine, Primaquine Phosphate is classified as belonging to the following category: Chloroquine (Aralen)
Taking Hibiscus sabdariffa tea along with chloroquine seems to reduce levels of chloroquine.
When taken together, Hibiscus sabdariffa tea significantly reduces the bioavailability of chloroquine. This may reduce its clinical effects. People taking chloroquine for the treatment or prevention of malaria should avoid Hibiscus sabdariffa tea.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Mahmoud, B. M., Ali, H. M., Homeida, M. M., and Bennett, J. L. Significant reduction in chloroquine bioavailability following coadministration with the Sudanese beverages Aradaib, Karkadi and Lemon. J.Antimicrob.Chemother. 1994;33(5):1005-1009.
Hibiscus Sabdariffa Overview
Hibiscus sabdariffa, also known as roselle or red sorrel, is a plant that belongs to the Malvaceae family and is native to several tropical regions of the world, including Africa, Asia, and the Caribbean. It is a perennial plant that has large flowers and a tart, cranberry-like flavor. It is a popular ingredient in beverages and is rich in antioxidants, vitamins and minerals, including vitamin C, calcium, and iron. Hibiscus sabdariffa is used in traditional medicine and is claimed to have a number of potential health benefits, including reducing blood pressure, improving digestion, and relieving stress and anxiety. It has also been used for improving liver health as well as a fever-reducer.
Hibiscus Sabdariffa - More Interactions
Hibiscus Sabdariffa interacts with 1038 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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