Lime - Phenergan (Promethazine) Interaction
Herbal: Lime
Also Known As: Citrus aurantifolia, Adam's Apple, Bara Nimbu, Bijapura, Citron Vert, Citronnier Vert, Huile de Lime, Italian Limetta, Key Lime, Lima, Lime Oil, Limette, Limettier, Turanj
Drug: Promethazine
Brand names:
Phenergan
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Promethazine is classified as belonging to the following category: Photosensitizing Drugs
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. .
Lime Overview
Lime (Citrus aurantifolia) is a citrus fruit native to Southeast Asia and is widely cultivated. It is a small, green, or yellow fruit with a sour, acidic taste and a fragrant, citrus aroma.
It is a rich source of vitamin C and antioxidants as well as other nutrients, such as flavonoids, which are plant compounds with purported antioxidant and anti-inflammatory properties.
Lime is used in traditional medicine to treat a variety of conditions, including digestive disorders, respiratory conditions, and skin problems. It is also used as a natural remedy for fever, headache, and other ailments. Lime is sometimes applied topically to the skin to treat cuts, wounds, and other skin conditions, and is used in aromatherapy to improve mood and reduce stress.
Promethazine Overview
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Promethazine is used to relieve the symptoms of allergic reactions such as allergic rhinitis (runny nose and watery eyes caused by allergy to pollen, mold or dust), allergic conjunctivitis (red, watery eyes caused by allergies), allergic skin reactions, and allergic reactions to blood or plasma products. Promethazine is used with other medications to treat anaphylaxis (sudden, severe allergic reactions) and the symptoms of the common cold such as sneezing, cough, and runny nose. Promethazine is also used to relax and sedate patients before and after surgery, during labor, and at other times. Promethazine is also used to prevent and control nausea and vomiting that may occur after surgery, and with other medications to help relieve pain after surgery. Promethazine is also used to prevent and treat motion sickness. Promethazine helps control symptoms, but will not treat the cause of the symptoms or speed recovery. Promethazine is in a class of medications called phenothiazines. It works by blocking the action of a certain natural substance in the body.
Lime - More Interactions
Lime interacts with 844 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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