Lion's Mane Mushroom - Soliris (Eculizumab) Interaction
Herbal: Lion's Mane Mushroom
Also Known As: Bearded Tooth, Crinière de Lion, Hedgehog Fungus, Hydne Hérisson, Lion's Mane, Monkey Head, Monkey's Head, Pom Pom, Pompom, Satyr's Beard, Tree Hedgehog, Yamabushitake
Drug: Eculizumab
Brand names:
Soliris
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 26, 2024
Interaction Details
Eculizumab is classified as belonging to the following category: Immunosuppressants
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
- Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.
Lion's Mane Mushroom Overview
Lion's mane mushroom (Hericium erinaceus) is a type of edible mushroom that grows on the dead trunks of several species of hardwood tree and is native to North America, Europe, and Asia. It is named for its long, shaggy spines that resemble the mane of a lion.
Lion's mane mushroom has been used as a dietary supplement for a number of purported health benefits. It is rich in antioxidants and may have anti-inflammatory properties, which may help to reduce the risk of chronic diseases such as heart disease. It is also believed to have neuroprotective effects and may help to improve cognitive function and memory, which is why it is often marketed as a 'nootropic'. In addition, lion's mane mushroom may have immune-boosting properties and may help to reduce the severity of colds and other infections.
Eculizumab Overview
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Eculizumab injection is used to treat paroxysmal nocturnal hemoglobinuria (PNH: a type of anemia in which too many red blood cells are broken down in the body, so there are not enough healthy cells to bring oxygen to all parts of the body). Eculizumab injection is also used to treat atypical hemolytic uremic syndrome (aHUS; an inherited condition in which small blood clots form in the body and may cause damage to the blood vessels, blood cells, kidneys, and other parts of the body). Eculizumab injection is also used to treat a certain form of myasthenia gravis (MG; a disorder of the nervous system that causes muscle weakness). It is also used to treat neuromyelitis optica spectrum disorder (NMOSD; an autoimmune disorder of the nervous system that affects eye nerves and the spinal cord) in certain adults. Eculizumab injection is in a group of medications called monoclonal antibodies. It works by blocking the activity of the part of the immune system that may damage blood cells in people with PNH and that causes clots to form in people with aHUS. It also works by blocking the activity of the part of the immune system that may damage certain parts of the central nervous system in people with NMOSD or by disrupting communication between nerves and muscles in people with MG.
Lion's Mane Mushroom - More Interactions
Lion's Mane Mushroom interacts with 314 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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