Noni - Keytruda (Pembrolizumab) Interaction
Herbal: Noni
Also Known As: Morinda citrifolia, Ba Ji Tian, Bois Douleur, Canarywood, Cheese Fruit, Hawaiian Noni, Hog Apple, Indian Mulberry, Indian Noni, Luoling, Mengkudu, Morinda, Mulberry, Nhau, Noni Juice, Nono, Nonu, Rotten Cheese Fruit, Ura, Wild Pine
Drug: Pembrolizumab
Brand names:
Keytruda
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2024
Interaction Details
There were no interactions found between Pembrolizumab and Noni. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Noni Overview
Noni (Morinda citrifolia) is a tropical fruit that is native to Southeast Asia and the Pacific Islands. It is also known by a variety of other names, including Indian mulberry, beach mulberry, and cheese fruit. Noni fruit is typically not eaten fresh due to its strong flavor and smell. Regardless, many parts of the plant, including the roots, fruit, stem, bark, leaves, and flowers are used to make juice, supplements, and other products.
Noni has a long history of use in traditional medicine. Some studies have suggested that noni may have potential health benefits, including the ability to reduce inflammation, improve immune function, and lower blood pressure. It is also thought to have antioxidant and anti-tumor effects.
Pembrolizumab Overview
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Pembrolizumab injection is used alone or in combination with other chemotherapy medications to treat certain types of melanoma (a type of skin cancer), Merkel cell carcinoma (MCC; a type of skin cancer), and cutaneous squamous cell carcinoma (CSCC; skin cancer). It is also used to prevent the return of melanoma after surgery. Pembrolizumab injection is also used alone and/or in combination with other chemotherapy medications to treat certain types of lung cancer (non-small-cell lung cancer; NSCLC), head and neck cancer, Hodgkin's lymphoma (Hodgkin's disease), primary mediastinal B-cell lymphoma (PMBCL; non-Hodgkin lymphoma), urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract), bladder cancer, colorectal cancer (cancer that begins in the large intestine), gastric cancer (cancer of the stomach), esophageal cancer (cancer of the tube that connects your throat to your stomach), cervical cancer (cancer that begins in the opening of the uterus [womb]), cancer of the endometrium (lining of the uterus), hepatocellular carcinoma (HCC; a type of liver cancer), renal cell carcinoma (RCC, a type of cancer that begins in the kidneys), breast cancer, and certain other solid tumors. Pembrolizumab injection is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.
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Your doctor will review your specific type of cancer and past treatment history and other available treatments to determine if pembrolizumab is right for you.
Noni - More Interactions
Noni interacts with 513 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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