Oregano - Cyramza (Ramucirumab) Interaction

Interaction Details

Pharmacist Analysis

Oregano (and oregano oil) supplements are generally considered safe and there is no indication that there is an interaction between the drug highlighted in this interaction monograph and oregano.

However, as with all supplements, it is important to talk to your doctor before starting anything new, so you can be appropriately monitored.

In terms of drug interactions that have been reported with oregano, below are some examples.

Anticoagulant; Antiplatelet Drugs

Anticoagulants and antiplatelet drugs work by slowing down or preventing blood clotting. While they are essential medications for individuals with certain conditions, they come with an increased risk of bleeding.

Some studies have reported that oregano oil may also increase the risk of bleeding, as it contains compounds that have antithrombin activity and can inhibit platelet aggregation.

Therefore, taking oregano oil along with anticoagulants or antiplatelet drugs may increase the risk of bleeding, bruising, and other adverse effects.

Anti-Diabetic Drugs

Several studies suggest that oregano supplements may help lower blood glucose (i.e., sugar) levels. In vitro and animal research has shown that oregano extracts might stimulate glucose uptake and reduce blood glucose levels.

Therefore, based on the available evidence, combining oregano oil with antidiabetic drugs could potentially cause blood sugar levels to drop too low, leading to hypoglycemia.

However, it is important to note that studies reporting that oregano can reduce blood glucose levels have not reported it causing hypoglycemia.

References

• Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. PubMed
• Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. PubMed
• Antithrombin activity of some constituents from Origanum vulgare. PubMed
• Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. PubMed

Ramucirumab Overview

• Ramucirumab injection is used alone and in combination with another chemotherapy medication to treat stomach cancer or cancer located in the area where the stomach meets the esophagus (the tube between the throat and stomach) when these conditions do not improve after treatment with other medications. Ramucirumab is also used in combination with docetaxel to treat a certain type of non-small cell lung cancer (NSCLC) that has spread to other parts of the body in people who have already been treated with other chemotherapy medications and have not improved or worsened. It is also used in combination with erlotinib (Tarceva) to a certain type of NSCLC that has spread to other parts of the body. Ramucirumab is also used in combination with other chemotherapy medications to treat cancer of the colon (large intestine) or rectum that has spread to other parts of the body in people that have already been treated with other chemotherapy medications and have not improved or worsened. Ramucirumab is also used alone to treat certain people with hepatocellular carcinoma (HCC; a type of liver cancer) who have already been treated with sorafenib (Nexafar). Ramucirumab is in a class of medications called monoclonal antibodies. It works by stopping the growth of cancer cells.

Oregano - More Interactions

Oregano interacts with 202 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.