Terminalia - Biktarvy (Bictegravir, Emtricitabine, Tenofovir Alafenamide) Interaction
Herbal: Terminalia
Also Known As: Terminalia arjuna, Abhaya, Amandier Indien, Arale, Arjuna, Axjun Argun, Badamier, Badamier chebule, Badamier Géant, Baheda, Bahera, Bahira, Bala Harade, Balera, Behada, Belleric Myrobalan, Belliric Myrobalan, Bhibitaki, Bibhitak, Bibitaki, Bihara, Black myrobalan
Drug: Bictegravir, Emtricitabine, Tenofovir Alafenamide
Brand names:
Biktarvy
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 26, 2024
Interaction Details
Bictegravir, Emtricitabine, Tenofovir Alafenamide is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Terminalia arjuna extract inhibits CYP3A4 enzymes and reduces CYP3A4 substrate metabolism.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Varghese A, Savai J, Pandita N, Gaud RS. In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin, and arjungenin on CYP3A4, CYP2D6, and CYP2C9 enzyme activity in human liver microsomes. Toxicology Reports. 2015(2):806-16.
Terminalia Overview
Terminalia is a genus of trees that are native to tropical and subtropical regions of the world. There are around 100 species of Terminalia, which are known for their hard, durable wood and their ability to grow in a variety of climates.
In traditional medicine, three species are of particular note, Terminalia arjuna, Terminalia bellirica, and Terminalia chebula. Various parts of these trees, including the bark, leaves, and fruit, are used as a natural remedy for digestive problems, such as constipation and diarrhea, and to boost the immune system. They are also believed to have anti-inflammatory properties, and they may be helpful in reducing inflammation and swelling in the body.
Bictegravir, Emtricitabine, Tenofovir Alafenamide Overview
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The combination of bictegravir, emtricitabine, and tenofovir AF is used to treat human immunodeficiency virus (HIV) infection in certain adults and children weighing at least 55 pounds (25 kg) who have not received antiretroviral treatment in the past or who have been stable on other antiretroviral treatment(s). Bictegravir is in a class of medications called integrase strand transfer inhibitors (INSTIs). Emtricitabine and tenofovir AF are in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). The combination of bictegravir, emtricitabine, and tenofovir AF works by decreasing the amount of HIV in the body. Although bictegravir, emtricitabine, and tenofovir AF will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of getting or transmitting the HIV virus to other people.
Terminalia - More Interactions
Terminalia interacts with 906 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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