Tianeptine - Ethanol Interaction Details

Interaction Details

Ethanol is classified as belonging to the following category: Alcohol (Ethanol)

Alcohol increases the clearance and might reduce the levels and clinical effects of tianeptine.
Clinical research shows that alcohol decreases tianeptine absorption rate and lowers tianeptine plasma levels by about 30%. Furthermore, an analysis of alcohol blood levels in 112 patients suggests that alcohol use disorder is associated with a 124% increase in clearance of tianeptine.

Interaction Rating

Moderate

Likelihood of Occurrence

Probable

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.

References

Grasela TH, Fiedler-Kelly JB, Salvadori C, Marey C, Jochemsen R. Development of a population pharmacokinetic database for tianeptine. Eur J Clin Pharmacol. 1993;45(2):173-9.
Salvadori C, Ward C, Defrance R, Hopkins R. The pharmacokinetics of the antidepressant tianeptine and its main metabolite in healthy humans--influence of alcohol co-administration. Fundam Clin Pharmacol. 1990;4(1):115-25.

Tianeptine - More Interactions

Tianeptine interacts with 276 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major	The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate	Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor	Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown	No interactions have been reported or no interaction data is currently available.