Watercress - Acetaminophen, Chlorzoxazone Interaction
Herbal: Watercress
Also Known As: Nasturtium officinale, Berro, Berros, Brunnenkresse, Crescione di Fonte, Cresson, Cresson au Poulet, Cresson Officinal, Indian Cress, Jal-Halim, Mizu-Garashi, Nasilord, Oranda-Garashi, Scurvy Grass, Selada-Air, Tall Nasturtium
Drug: Acetaminophen, Chlorzoxazone
Brand names:
Parafon Forte, Extra Strength Tylenol Aches & Strains, Acetazone Forte
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jul 22, 2023
Interaction Details
Acetaminophen, Chlorzoxazone is classified as belonging to the following category: Chlorzoxazone (Parafon Forte, Paraflex)
Watercress might reduce the metabolism of chlorzoxazone and increase its effects and side effects. Clinical research in healthy volunteers shows that a single ingestion of watercress 50 grams increases the chlorzoxazone plasma concentration-time curve by about 56% and increases its half-life by about 53%.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Leclercq I, Desager JP, Horsmans Y. Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress. Clin Pharmacol Ther 1998;64:144-9.
Watercress Overview
Watercress - More Interactions
Watercress interacts with 6 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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Drug descriptions are provided by MedlinePlus.