American Ivy - Zestoretic (Hydrochlorothiazide, Lisinopril) Interaction
Herbal: American Ivy
Also Known As: Parthenocissus quinquefolia, American Woodbine, Creeper, False Grapes, Five Leaves, Ivy, Parra Virgen, Vigne Vierge, Virginia Creeper, Wild Woodbine, Wild Woodvine, Woody Climber
Drug: Hydrochlorothiazide, Lisinopril
Brand names:
Zestoretic, Prinzide
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 06, 2024
Interaction Details
Hydrochlorothiazide, Lisinopril is classified as belonging to the following category: Thiazide Diuretics
The berries of American ivy contain up to 2% oxalic acid, which can be toxic because it has the potential to cause kidney failure by precipitating solid calcium oxalate. Thiazide diuretics are often prescribed to decrease urinary calcium levels and prevent the formation of calcium oxalate kidney stones. Consequently, the berries of American ivy and thiazide diuretics may have opposing effects in this context, as the diuretics work to lower urinary calcium levels while the oxalic acid in the berries could potentially increase the risk of kidney stone formation. It is important to note that medicinal supplements utilizing American ivy generally only make use of the bark, not the berries.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
American Ivy Overview
Parthenocissus quinquefolia, commonly known as American ivy, Virginia creeper, or five-leaved ivy, is a climbing shrub native to North America and cultivated worldwide. It is most often used for its ornamental appeal. Its bark is used in medicine and contains constituents such as terpenoids, flavonoids, saponins, and cardiac glycosides. While sometimes used for digestive disorders and to stimulate sweating, there is no strong evidence to support these uses. The berries of American ivy, which contain 2% oxalic acid, are considered poisonous. It is important to note that American ivy is different from English ivy, or Hedera helix, which is more commonly used in over-the-counter supplements and medicine, mostly for its respiratory effects.
Hydrochlorothiazide, Lisinopril Overview
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The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
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High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
American Ivy - More Interactions
American Ivy interacts with 56 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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