Concern With Taking Cissus Quadrangularis Before Surgery

Answer

Thank you for reaching out to us!

Calzbone, one of the ingredients in 'Osteo MD' is a patented extract of 'Cissus quadrangularis', a vine that belongs to the grape family.

Dietary supplements containing Cissus quadrangularis are marketed for a wide variety of conditions, including supporting weight loss and bone health.

Calzbone, in particular, has been studied for its effects on bone fracture healing time.

One study, published in the journal 'Antiseptic,' although very small (I've included the reference at the end of this answer), reported that Calzbone, 250 mg orally three times daily, decreased the average fracture healing time of long bones of the leg from 16-20 weeks to 12-14 weeks. Again, this was a small study, but it at least shows some potential as a positive measure for healing fractures.

Calzbone (Cissus Quadrangularis) Interactions

I could find little evidence of clinically significant interactions between Cissus quadrangularis and prescription medications. Additionally, it appears to be very well tolerated based on the studies I reviewed. It has been reported to cause some minor gastrointestinal issues as well as insomnia, but the rates of these side effects were essentially the same, or less, than what was reported in those taking a placebo. I did not see any reports of bleeding.

Our own herbal interaction checker only lists interactions with antidiabetic agents. For example, we list an interaction between Cissus quadrangularis and Januvia (an antidiabetic drug) based on the fact that Cissus quadrangularis may lower blood sugar (which could have additive effects when combined with other antidiabetic agents).

Based on my research, I did not see any evidence that Cissus quadrangularis affects blood coagulation or would be a concern prior to having sinus surgery. Having said that, there is certainly only very limited data to go off of, so I strongly suggest talking to your surgeon regarding instructions pre-surgery. They should provide clear instructions regarding what is, and is not, safe to take before surgery.

Final Words

Thank you again for your question, and I hope you found this helpful.