Cissus Quadrangularis Interactions Overview

Check For Interactions With Cissus Quadrangularis

Cissus Quadrangularis

Also known as
  • Vitis quadrangularis
  • Veldt Grape
  • Adamant Creeper
Cissus Quadrangularis Cissus quadrangularis is a vine plant from the grape family, traditionally used for promoting bone fracture healing and treating digestive disorders. It contains various beneficial compounds like flavonoids, steroids, and antioxidants. Studies in animals have shown that Cissus quadrangularis may stimulate new bone growth, promote the activity of bone-building cells called osteoblasts, increase bone thickness, and reduce the activity of bone-degrading cells called osteoclasts. Research suggests these bone-promoting effects are mediated by specific molecular pathways and increasing the expression of key bone development genes in osteoblasts. Other uses of Cissus quadrangularis include supporting weight loss, blood sugar control and improving joint pain.
There are 84 drugs known to interact with Cissus Quadrangularis

Are Cissus Quadrangularis Supplements Standardized?

There are several over the counter dietary supplements that contain patented forms of Cissus quadrangularis extracts. Some patented forms include:

  • Calzbone, Verdure Sciences
  • SuperCissus, USPlabs
  • CQR-300; Gateway Health Alliance

Typically, patented products are marketed for specific uses. For example, 'Calzbone' is most often marketed for bone health while CQR-300 is often marketed for weight management.

Phytochemical Composition of Cissus Quadrangularis

The entire plant (Cissus Quadrangularis), including its leaves, stems, and roots, is believed to have therapeutic properties. This plant is rich in various compounds that contribute to its potential medicinal benefits.

One of the major groups of compounds found in Cissus quadrangularis are flavonoids, which are plant-based antioxidants.

It also contains ketosteroids, lipids, and stilbenes, such as pallidol, quadrangularin A, resveratrol, piceatannol, and perthenocissin. Additionally, the plant is a source of triterpenoids, including epifriedelinol, isoarborenol, and lupenone.

Other notable constituents of Cissus quadrangularis include:

  1. Biphenyl compounds like 3,3',4,4'-tetrahydroxybiphenyl
  2. Cysteine proteases (enzymes)
  3. Amyrins (alpha, beta, and delta)
  4. Delta-amyrone
  5. Indanes
  6. Iridoids, such as picroside-1, 6-O-[2,3-dimethoxy]-trans-cinnamoyl catalpol, and 6-O-meta-methoxy-benzoyl catalpol
  7. Onocer-7-ene-3alpha,21beta-diol
  8. Phytosterols like beta-sitosterol and beta-sitosterol glycoside
  9. Polyphenols
  10. Quercetin and quercetrin (flavonoid compounds)
  11. Tannins

The plant is also a source of various vitamins and minerals, including vitamin C (ascorbic acid), carotenoids like carotene, calcium, and vitamin E.

Drugs that interact with Cissus Quadrangularis

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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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