Herb & supplement monograph

Hydrazine Sulfate Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Hydrazine Sulfate interacts with medications. The heart of this page is the interaction list — every drug Hydrazine Sulfate is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Hydrazine Sulfate is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Interaction report

Drugs that interact with Hydrazine Sulfate

98 medications have a known interaction with Hydrazine Sulfate, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Hydrazine Sulfate using our pharmacist-reviewed interaction data.

AI summaries are generated from our Hydrazine Sulfate interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Hydrazine Sulfate combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Hydrazine Sulfate affects

Every type of medication (drug category) Hydrazine Sulfate is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories Hydrazine Sulfate interacts with

Antidiabetes DrugsIsoniazidMonoamine Oxidase Inhibitors (maois)

Antidiabetes Drugs

Theoretically, taking hydrazine sulfate concomitantly with antidiabetes drugs could increase the risk for hypoglycemia.
Animal research shows that hydrazine sulfate lowers blood glucose. Hypoglycemia has also been reported in some patients taking hydrazine sulfate during clinical studies. Monitor blood glucose levels closely.

Likelihood Possible Evidence B

Isoniazid

Theoretically, concurrent use of isoniazid and hydrazine sulfate might increase the risk for liver damage.
Hydrazine sulfate is a metabolite of isoniazid. Animal research shows that hydrazine sulfate might be responsible for isoniazid-induced hepatotoxicity.

Likelihood Possible Evidence D

Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use with other MAOIs might increase the effects and adverse effects associated with MAOIs.
Medications with hydrazine chemical moieties (e.g., phenelzine) are known to inhibit monoamine oxidase. Theoretically, hydrazine sulfate acts as an MAOI.

Likelihood Possible Evidence D

Monograph

Hydrazine Sulfate: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Hydrazine sulfate is a synthetic industrial chemical that was promoted as an alternative cancer treatment, but well-designed clinical trials found it does not help people with cancer live longer or feel better. It carries real risks, including serious nerve and liver toxicity, and is not approved or recommended for any medical use. Talk with your doctor or pharmacist before considering it.

Part used: Not applicable (synthetic industrial chemical)
Common forms: Capsules, tablets, oral solution, and injectable forms (not legally available as a supplement in the U.S.)

People commonly use it for

Cancer-related weight loss (cachexia)
Cancer treatment (unproven)
Appetite stimulation
Improving quality of life in advanced illness

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallBest avoided

Rigorous trials showed no benefit and it can cause serious harm.

PregnancyPossibly Unsafe

When used orally. Hydrazine sulfate has been linked to cases of significant adverse effects including hepatotoxicity, encephalopathy, and death.

Read the full pregnancy detail

BreastfeedingPossibly Unsafe

When used orally. Hydrazine sulfate has been linked to cases of significant adverse effects including hepatotoxicity, encephalopathy, and death.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Hydrazine sulfate is a man-made chemical, not an herb or plant product. The same base chemical, hydrazine, is used in industry for things like rocket fuel, manufacturing, and metal processing. It is a white, crystal-like powder.

Starting in the 1970s, hydrazine sulfate was promoted as an alternative treatment for cancer. The idea was that it might slow down the severe weight loss and muscle wasting (called cachexia) that often happens in people with advanced cancer. It became popular through some clinics and word of mouth, but it was never approved as a medicine in the United States.

Today hydrazine sulfate is not sold as a standard dietary supplement and is not recommended by mainstream cancer organizations. Any product claiming to contain it should be treated with great caution.

How it works

The original theory was that hydrazine sulfate could block a step in the body's metabolism that lets tumors "steal" energy and cause wasting. Supporters thought it might interfere with how the body turns lactate back into glucose (a process called gluconeogenesis), which could in theory reduce weight loss in cancer.

This idea came mostly from laboratory and early research, not from solid proof in people. When tested in real patients, the proposed effect did not translate into longer survival or better health. So while the mechanism sounds plausible on paper, the human evidence did not support it.

Effectiveness

Does Hydrazine Sulfate work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 6 uses evaluated

1 Leans ineffective 5 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

Likely Ineffective Lung cancer