Hydrazine Sulfate + Pralsetinib
Pralsetinib brand name: Gavreto.
We found no known interaction between Hydrazine Sulfate and Pralsetinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pralsetinib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Hydrazine Sulfate and Pralsetinib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Pralsetinib and Hydrazine Sulfate in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Hydrazine Sulfate safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Pralsetinib
Interactions in our licensed database are recorded against drug classes, not just single drug names. Pralsetinib is filed under 5 classifications — including qt interval-prolonging drugs, p-glycoprotein substrates, hepatotoxic drugs. Hydrazine Sulfate has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), isoniazid (moderate) and monoamine oxidase inhibitors (maois) (moderate) — and none of Pralsetinib’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Hydrazine Sulfate Does Interact With Other Medications
Hydrazine Sulfate has 98 moderate known drug interactions in our database — Pralsetinib isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Hydrazine Sulfate
We haven’t checked that one against Hydrazine Sulfate yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Hydrazine Sulfate. Pick one to open its full report.
Hydrazine Sulfate in Pregnancy & Breastfeeding
When used orally. Hydrazine sulfate has been linked to cases of significant adverse effects including hepatotoxicity, encephalopathy, and death.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Pralsetinib Products Have a Food Rule — Hydrazine Sulfate Should Not Break It
At least one FDA label for a product containing Pralsetinib says to take it on an empty stomach. Most supplements — Hydrazine Sulfate included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Pralsetinib on its own and move Hydrazine Sulfate to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pralsetinib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.1 , 14 ) The recommended dosage in adults and pediatric patients 12 years and older is 400 mg orally once daily on an empty stomach (no food intake for at least 2 hours before and at least 1 hour after taking GAVRETO).
From the Dosage and Administration section of the FDA label we read for Pralsetinib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Pralsetinib Is Prescribed For, and What Hydrazine Sulfate Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Pralsetinib is a prescription medicine with approved uses on its FDA label. Hydrazine Sulfate is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Pralsetinib is prescribed for: Gavreto (pralsetinib) is used to treat adults with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) — a type of lung cancer that has spread and carries a specific genetic alteration detected by an FDA-approved test. Gavreto is also approved for adults and children aged 12 and older with advanced or metastatic RET fusion-positive thyroid cancer who need systemic (whole-body) treatment and whose cancer no longer responds to radioactive iodine (when radioactive iodine is an appropriate option). This thyroid cancer use is under accelerated approval, meaning continued approval depends on results from confirmatory clinical trials.
Hydrazine Sulfate has been studied for:
-
Lung cancer studied, not established Hydrazine Sulfate has been studied for this. Natural Medicines rates the evidence: Likely Ineffective Read what the research shows
Hydrazine Sulfate for lung cancer
Taking hydrazine sulfate as an adjunct to chemotherapy is not beneficial for treating non-small cell lung cancer (NSCLC) in most patients.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pralsetinib on your own; if you are taking Hydrazine Sulfate for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Pralsetinib
This page covers Hydrazine Sulfate only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pralsetinib page lists 181 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).
By severity: 11 major · 134 moderate · 36 minor.
From our pharmacist’s overview on the Pralsetinib page
“With pralsetinib (Gavreto), a targeted therapy for RET-driven lung and thyroid cancers, I would treat this list as required reading rather than background noise. Most of the interactions change how much of the drug the body actually gets: grapefruit can push its levels higher, while St.”
Reviewed by 2 · Jul 18, 2026
Where Hydrazine Sulfate and Pralsetinib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,183 of 1,452 supplements looked up here in the last 7 days
#2,164 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hydrazine Sulfate reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Hydrazine Sulfate and Pralsetinib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Hydrazine Sulfate
What is Hydrazine Sulfate?
- Cancer-related weight loss (cachexia)
- Cancer treatment (unproven)
- Appetite stimulation
- Improving quality of life in advanced illness
Hydrazine sulfate is a synthetic industrial chemical that was promoted as an alternative cancer treatment, but well-designed clinical trials found it does not help people with cancer live longer or feel better. It carries real risks, including serious nerve and liver toxicity, and is not approved or recommended for any medical use. Talk with your doctor or pharmacist before considering it.
Not applicable (synthetic industrial chemical) · Capsules, tablets, oral solution, and injectable forms (not legally available as a supplement in the U.S.)
An interaction check asks whether these two react with each other — it does not ask whether Hydrazine Sulfate is a good idea for someone in your situation. Here is what our Hydrazine Sulfate record says about it on its own.
Hydrazine Sulfate: dosing
There is no safe or recommended dose of hydrazine sulfate, and it is not approved for medical use. Because it is not a legitimate supplement, no standardized, evidence-based dosing exists.We do not recommend taking it at all.
From our Hydrazine Sulfate monograph — the full record covers uses, side effects and every documented interaction.
About Pralsetinib
What Is Pralsetinib Used For?
Brand name: Gavreto
Gavreto (pralsetinib) is used to treat adults with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) — a type of lung cancer that has spread and carries a specific genetic alteration detected by an FDA-approved test.
Gavreto is also approved for adults and children aged 12 and older with advanced or metastatic RET fusion-positive thyroid cancer who need systemic (whole-body) treatment and whose cancer no longer responds to radioactive iodine (when radioactive iodine is an appropriate option). This thyroid cancer use is under accelerated approval, meaning continued approval depends on results from confirmatory clinical trials.
Most-Reported Side Effects for Pralsetinib
From FAERS, the FDA’s public side-effect reporting system (1,788 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Hydrazine Sulfate
Browse every other medication we’ve checked against Hydrazine Sulfate — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
98 interactions
- Insulin (rdna) ›
- Glyburide ›
- Insulin (pork) ›
- Insulin (human) ›
- Amphetamine ›
- Selegiline ›
- Acarbose ›
- Insulin Glargine ›
- Isoniazid ›
- Semaglutide ›
- Chlorpropamide ›
- Exenatide ›
- Glipizide ›
- Glucagon ›
- Insulin Lispro ›
- Metformin ›
- Moclobemide ›
- Repaglinide ›
- Sitagliptin ›
- Tirzepatide ›
- Acetohexamide ›
- Albiglutide ›
- Alogliptin ›
- Canagliflozin ›
- Dapagliflozin ›
- Dasiglucagon Hydrochloride ›
- Dulaglutide ›
- Empagliflozin ›
- Ertugliflozin ›
- Exenatide Synthetic ›
- Gliclazide ›
- Glimepiride ›
- Glucose ›
- Inhaled Insulin ›
- Insulin ›
- Insulin (bovine) ›
- Insulin Aspart ›
- Insulin Degludec ›
- Insulin Determir ›
- Insulin Glargine (rdna) ›
- Insulin Glargine Recombinant ›
- Insulin Glulisine (rdna) ›
- Insulin Lispro Recombinant ›
- Insulin Lispro-aabc ›
- Isocarboxazid ›
- Linagliptin ›
- Liraglutide ›
- Liraglutide Recombinant ›
- Lixisenatide ›
- Metformin Hydrochloride ›
- Metformin Xr ›
- Miglitol ›
- Muraglitazar ›
- Nateglinide ›
- Ozanimod Hydrochloride ›
- Phenelzine Sulfate ›
- Pioglitazone ›
- Pramlintide ›
- Rasagiline ›
- Rosiglitazone Maleate ›
Showing 60 of 98 moderate interactions — see all 98 on the Hydrazine Sulfate page.
No interaction 2,731 drugs checked — show the list
We also checked Hydrazine Sulfate against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Candesartan Cilexetil ›
- Acetaminophen, Aspirin, Caffeine ›
Showing the 60 most looked-up of 2,731 medications checked with no known interaction — see the full Hydrazine Sulfate list.
Hydrazine Sulfate References
The 18 references that drive our Hydrazine Sulfate monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Chlebowski RT, Bulcavage L, Grosvenor M, et al. Hydrazine sulfate in cancer patients with weight loss. A placebo-controlled clinical experience. Cancer 1987;59:406-10. PubMed
- Kaegi E. Unconventional therapies for cancer: 4. Hydrazine sulfate. Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative. CMAJ 1998;158:1327-30.
- Hainer MI, Tsai N, Komura ST, Chiu CL. Fatal hepatorenal failure associated with hydrazine sulfate. Ann Intern Med 2000;133:877-80. PubMed
- Gershanovich ML, Danova LA, Ivin BA, Filov VA. Results of clinical study antitumor action of hydrazine sulfate. Nutr Cancer 1981;3:7-12..
- Ochoa M Jr, Wittes RE, Krakoff IH. Trial of hydrazine sulfate (NSC-150014) in patients with cancer. Cancer Chemother Rep 1975;59:1151-4.
- Sarich TC, Adams SP, Petricca G, Wright JM. Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidase inhibitor. J Pharmacol Exp Ther 1999;289:695-702. DOI
- Black M, Hussain H. Hydrazine, cancer, the Internet, isoniazid, and the liver. Ann Intern Med 2000;133:911-3. PubMed
- Gershanovich, M. L., Danova, L. A., Kondratyev, V. B., Malyugina, L. L., Stukov, A. N., Seitz, J. F., and Filov, V. A. Clinical data on the antitumor activity of hydrazine sulfate. Cancer Treat.Rep. 1976;60(7):933-935.
- Nagappan, R. and Riddell, T. Pyridoxine therapy in a patient with severe hydrazine sulfate toxicity. Crit Care Med. 2000;28(6):2116-2118. PubMed
- Wiernikowski, A. and Langer, D. [Acute poisoning with orally ingested hydrazine hydrate]. Polski Tygodnik Lekarski 7-21-1975;30(29):1231-1232.
- Gold, J. Use of hydrazine sulfate in terminal and preterminal cancer patients: results of investigational new drug (IND) study in 84 evaluable patients. Oncology 1975;32(1):1-10. PubMed
- Spremulli, E., Wampler, G. L., and Regelson, W. Clinical study of hydrazine sulfate in advanced cancer patients. Cancer Chemother.Pharmacol. 1979;3(2):121-124. PubMed
- Laszlo, J., Durant, J., and Loeb, V. Clinical pharmacologic study of 1-acetyl-2-picolinoyl hydrazine (NSC- 68626). Cancer Chemother Rep 1969;53(2):131-134.
- Freese, E., Sklarow, S., and Freese, E. B. DNA damage caused by antidepressant hydrazines and related drugs. Mutat.Res 1968;5(3):343-348. PubMed
- Reid, F. J. Hydrazine poisoning. Br Med J 11-20-1965;5472:1246.
- Kulkarni, S. G. and Nawaz, M. Acute hepatic encephalopathy following hydrazine - hydrate poisoning. J Assoc Physicians India 1982;30(3):171-172.
- Filov, V. A., Gershanovich, M. L., Danova, L. A., and Ivin, B. A. Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients. Invest New Drugs 1995;13(1):89-97. PubMed
- Suzuki, H., Tominaga, T., Mizuno, H., Kouno, M., Suzuki, M., Kato, Y., Sato, A., Okabe, K., Uchikoshi, T., Maezono, K., and . Ethanol and hydrazine sulfate induced chronic hepatic injury in rats: the curative effect of administration of glucogenic amino
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Hydrazine Sulfate and Pralsetinib Together: Common Questions
Is it safe to take Hydrazine Sulfate with Pralsetinib?
Do Hydrazine Sulfate and Pralsetinib have any of the same side effects?
Should I take Hydrazine Sulfate and Pralsetinib at the same time of day?
Are Hydrazine Sulfate and Pralsetinib used for the same thing?
How was the Hydrazine Sulfate and Pralsetinib combination checked?
Does Hydrazine Sulfate interact with any other medications?
Does Pralsetinib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.