Pralsetinib

Generic name: Pronounced as (pral" se' ti nib)
Brand names
  • Gavreto®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2021

Pralsetinib is used to treat a certain type of non small-cell lung cancer (NSCLC) in adults that has spread to other parts of the body. It is also used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that is getting worse or that has spread to other parts of the body. Pralsetinib is used to treat a certain type of thyroid cancer in adults and children 12 years of age and older that is getting worse or that has spread to other parts of the body and cannot be treated with radioactive iodine. Pralsetinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply.

Pralsetinib comes as a capsule to take by mouth. It is usually taken once daily on an empty stomach, at least 2 hours before and at least 1 hour after a meal. Take pralsetinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pralsetinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you vomit after taking pralsetinib, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose or temporarily or permanently stop your treatment if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with pralsetinib.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking pralsetinib,

  • tell your doctor and pharmacist if you are allergic to pralsetinib, any other medications, or any of the ingredients in pralsetinib capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungal medications including itraconazole (Onmel, Sporanox) and ketoconazole; clarithromycin (in Biaxin); certain HIV medications such as efavirenz (Sustiva, in Atripla, Symfi), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra, Viekira Pak), and saquinavir (Invirase); oxcarbazepine (Oxtellar XR, Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, in Oseni, Duetact); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had lung or breathing problems other than lung cancer, bleeding problems, high blood pressure, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan to father a child. Pralsetinib may interfere with the action of hormonal contraceptives (birth control pills, patches, rings, implants, or injections), so you should not use these as your only method of birth control during your treatment. You must use a non-hormonal birth control such as a barrier method (device that blocks sperm from entering the uterus such as a condom or a diaphragm). Ask your doctor to help you choose a method of birth control that will work for you. If you are female, you will need to have a pregnancy test before you start treatment, and you should use non-hormonal birth control to prevent pregnancy during your treatment and for 2 weeks after your final dose. If you are a male and your partner can become pregnant, you should use effective birth control to prevent pregnancy during your treatment and for 1 week after your final dose. You should know that this medication may decrease fertility in men and women; however, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. If you or your partner becomes pregnant while taking pralsetinib, call your doctor. Pralsetinib may harm the fetus.

  • tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while taking pralsetinib and for 1 week after your final dose.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking pralsetinib.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pralsetinib. Your doctor may tell you not to take pralsetinib 5 days before your surgery and will tell you when to start taking the medication again.

  • you should know that your blood pressure may increase during your treatment with pralsetinib. Your doctor will monitor your blood pressure carefully, and may prescribe medication to treat high blood pressure if it develops.

  • you should know that you may experience tumor lysis syndrome (TLS; a condition caused by the fast breakdown of cancer cells that can cause kidney failure and other complications) during your treatment with pralsetinib. To help reduce your risk of experiencing TLS, your doctor may ask you to drink water before and during your treatment, and each time your dose is increased. In addition, your doctor will give you a medication to take before starting and during your treatment to help prevent this side effect. If you experience any of the following symptoms of TLS, call your doctor immediately: fever, chills, nausea, vomiting, confusion, shortness of breath, seizures, irregular heartbeat, dark or cloudy urine, unusual tiredness, or muscle or joint pain.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose on the same day as soon as you remember it. Then, continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Pralsetinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • constipation

    • diarrhea

    • dry mouth

    • muscle or bone pain

    • swelling of hands, ankles, or feet

  • Some side effects can be serious. If you experience any of these symptoms or those listed in SPECIAL PRECAUTIONS, call your doctor immediately or get emergency medical treatment:

    • confusion, headache, shortness of breath, dizziness, or chest pain

    • fever, shortness of breath, or cough

    • pale skin, fatigue, or shortness of breath

    • yellowing of skin or eyes, dark-colored urine, bleeding or bruising more easily than normal, loss of appetite, decreased energy, or pain on right side of stomach area

    • black and tarry stools

    • red blood in stools

    • bloody vomit

    • vomiting material that looks like coffee grounds

    • coughing up blood

    • unusual bleeding or bruising

    • unusual vaginal bleeding

    • frequent nose bleeds

    • drowsiness, confusion, headache, or difficulty speaking

  • Pralsetinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order a lab test before your treatment to find out if your cancer can be treated with pralsetinib. Your doctor will also order certain lab tests before, during, and after your treatment to check your body's response to pralsetinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide Pralsetinib may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Pralsetinib.
Leflunomide Leflunomide Pralsetinib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine Delavirdine The serum concentration of Pralsetinib can be increased when it is combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Pralsetinib.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Pralsetinib.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Pralsetinib.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Pralsetinib.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Pralsetinib.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Pralsetinib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Erythromycin can be increased when it is combined with Pralsetinib.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Pralsetinib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Pralsetinib may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Pralsetinib.
Ranitidine Ranitidine The excretion of Ranitidine can be decreased when combined with Pralsetinib.
Reserpine Reserpine The serum concentration of Pralsetinib can be increased when it is combined with Reserpine.
Sumatriptan Sumatriptan Pralsetinib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Pralsetinib.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be decreased when combined with Pralsetinib.
Fluconazole Injection Fluconazole Injection The serum concentration of Pralsetinib can be increased when it is combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Pralsetinib.
Levofloxacin Injection Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Pralsetinib.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Pralsetinib.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Pralsetinib.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Pralsetinib.
Zidovudine Injection Zidovudine Injection Pralsetinib may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Cyclosporine Cyclosporine The serum concentration of Pralsetinib can be increased when it is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Pralsetinib.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Pralsetinib.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Pralsetinib.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Pralsetinib.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Pralsetinib.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Pralsetinib.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Telmisartan Telmisartan Pralsetinib may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Zaleplon Zaleplon The metabolism of Zaleplon can be decreased when combined with Pralsetinib.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Pralsetinib.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Pralsetinib.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Pralsetinib.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Pralsetinib.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Pralsetinib.
Olmesartan Olmesartan The risk or severity of liver damage can be increased when Olmesartan is combined with Pralsetinib.
Zonisamide Zonisamide The serum concentration of Pralsetinib can be increased when it is combined with Zonisamide.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Pralsetinib.
Ezetimibe Ezetimibe Pralsetinib may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir The serum concentration of Atazanavir can be increased when it is combined with Pralsetinib.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Pralsetinib.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Pralsetinib.
Rosuvastatin Rosuvastatin Pralsetinib may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Pralsetinib.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Pralsetinib.
Aprepitant Aprepitant The metabolism of Aprepitant can be decreased when combined with Pralsetinib.
Emtricitabine Emtricitabine The excretion of Emtricitabine can be decreased when combined with Pralsetinib.
Tegaserod Tegaserod Pralsetinib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Tadalafil Tadalafil The metabolism of Tadalafil can be decreased when combined with Pralsetinib.
Progesterone Progesterone Progesterone may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Pralsetinib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pralsetinib.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Pralsetinib.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Pralsetinib.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Pralsetinib.
Tinidazole Tinidazole Pralsetinib may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The risk or severity of liver damage can be increased when Pralsetinib is combined with Bosentan.
Cefditoren Cefditoren The excretion of Cefdinir can be decreased when combined with Pralsetinib.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Pralsetinib.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Pralsetinib.
Ganciclovir Ganciclovir The excretion of Ganciclovir can be decreased when combined with Pralsetinib.
Voriconazole Voriconazole The serum concentration of Voriconazole can be increased when it is combined with Pralsetinib.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Pralsetinib.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Pralsetinib.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Pralsetinib.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Pralsetinib.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Pralsetinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Pralsetinib.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Pralsetinib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Pralsetinib.
Clofarabine Injection Clofarabine Injection Pralsetinib may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection Pralsetinib may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Pralsetinib.
Darunavir Darunavir The serum concentration of Pralsetinib can be increased when it is combined with Darunavir.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Pralsetinib.
Sorafenib Sorafenib The serum concentration of Pralsetinib can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Pralsetinib can be increased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Lapatinib Lapatinib The serum concentration of Pralsetinib can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The serum concentration of Pralsetinib can be increased when it is combined with Dasatinib.
Ivermectin Ivermectin Pralsetinib may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Temsirolimus Temsirolimus The serum concentration of Pralsetinib can be increased when it is combined with Temsirolimus.
Nilotinib Nilotinib The serum concentration of Pralsetinib can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Pralsetinib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Pralsetinib.
Budesonide Budesonide Pralsetinib may decrease the excretion rate of Budesonide which could result in a higher serum level.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Pralsetinib.
Mitoxantrone Injection Mitoxantrone Injection Pralsetinib may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Pralsetinib.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Pralsetinib.
Flecainide Flecainide The excretion of Flecainide can be decreased when combined with Pralsetinib.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Pralsetinib.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Pralsetinib.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Pralsetinib.
Mitotane Mitotane The serum concentration of Pralsetinib can be decreased when it is combined with Mitotane.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Pralsetinib.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Pralsetinib.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Pralsetinib.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Pralsetinib.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Pralsetinib.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Pralsetinib.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Pralsetinib.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Pralsetinib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Pralsetinib.
Dronedarone Dronedarone The serum concentration of Pralsetinib can be increased when it is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Pralsetinib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Pralsetinib.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Pralsetinib.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Pralsetinib.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Pralsetinib.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Pralsetinib.
Pitavastatin Pitavastatin Pralsetinib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Pralsetinib.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Pralsetinib.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Pralsetinib.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Pralsetinib can be increased when it is combined with Cabazitaxel.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Pralsetinib.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Pralsetinib.
Linagliptin Linagliptin The serum concentration of Pralsetinib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Telaprevir Telaprevir The serum concentration of Pralsetinib can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Pralsetinib.
Rivaroxaban Rivaroxaban Pralsetinib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The serum concentration of Pralsetinib can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Pralsetinib.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Pralsetinib.
Vandetanib Vandetanib The serum concentration of Pralsetinib can be increased when it is combined with Vandetanib.
Clobazam Clobazam The serum concentration of Clobazam can be increased when it is combined with Pralsetinib.
Vemurafenib Vemurafenib The serum concentration of Pralsetinib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Ivacaftor Ivacaftor The serum concentration of Pralsetinib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Pralsetinib.
Crizotinib Crizotinib The serum concentration of Pralsetinib can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Pralsetinib.
Naloxone Injection Naloxone Injection The serum concentration of Pralsetinib can be increased when it is combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Pralsetinib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Pralsetinib can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The serum concentration of Pralsetinib can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Pralsetinib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Pralsetinib can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Pralsetinib.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Pralsetinib.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Pralsetinib.
Ponatinib Ponatinib The serum concentration of Pralsetinib can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Pralsetinib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Pralsetinib.
Apixaban Apixaban Pralsetinib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The serum concentration of Pralsetinib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Pralsetinib can be increased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Pralsetinib.
Dolutegravir Dolutegravir Pralsetinib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Pralsetinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Pralsetinib.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Pralsetinib.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Pralsetinib.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Pralsetinib.
Lomitapide Lomitapide The serum concentration of Pralsetinib can be increased when it is combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Pralsetinib.
Simeprevir Simeprevir The serum concentration of Pralsetinib can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir Pralsetinib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Pralsetinib.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Pralsetinib.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Pralsetinib.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Pralsetinib.
Testosterone Injection Testosterone Injection Pralsetinib may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar Vorapaxar The serum concentration of Pralsetinib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Pralsetinib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Pralsetinib.
Olaparib Olaparib The metabolism of Pralsetinib can be increased when combined with Olaparib.
Caspofungin Injection Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Pralsetinib.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Pralsetinib.
Riociguat Riociguat Pralsetinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nintedanib Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Pralsetinib.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Pralsetinib.
Palbociclib Palbociclib The serum concentration of Pralsetinib can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib Pralsetinib may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Pralsetinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Pralsetinib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Pralsetinib.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Pralsetinib can be increased when it is combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Pralsetinib.
Flibanserin Flibanserin The serum concentration of Pralsetinib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Pralsetinib can be increased when it is combined with Rolapitant.
Daclatasvir Daclatasvir The serum concentration of Pralsetinib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Pralsetinib.
Eluxadoline Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Pralsetinib.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Pralsetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Pralsetinib.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Pralsetinib.
Alectinib Alectinib The metabolism of Pralsetinib can be increased when combined with Alectinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Pralsetinib.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Pralsetinib.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Pralsetinib can be decreased when it is combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Pralsetinib.
Venetoclax Venetoclax The serum concentration of Pralsetinib can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Pralsetinib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Pralsetinib.
Obeticholic Acid Obeticholic Acid The risk or severity of adverse effects can be increased when Pralsetinib is combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Pralsetinib.
Rucaparib Rucaparib The serum concentration of Pralsetinib can be increased when it is combined with Rucaparib.
Ribociclib Ribociclib The serum concentration of Ribociclib can be increased when it is combined with Pralsetinib.
Brigatinib Brigatinib The metabolism of Pralsetinib can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Pralsetinib.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Pralsetinib.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Pralsetinib.
Safinamide Safinamide Safinamide may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Pralsetinib.
Midostaurin Midostaurin The serum concentration of Midostaurin can be increased when it is combined with Pralsetinib.
Neratinib Neratinib The serum concentration of Pralsetinib can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The serum concentration of Pralsetinib can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Pralsetinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Pralsetinib.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Pralsetinib.
Delafloxacin Delafloxacin Pralsetinib may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Pralsetinib can be increased when combined with Abemaciclib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Pralsetinib.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Pralsetinib.
Letermovir Letermovir Letermovir may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Ertugliflozin Ertugliflozin Pralsetinib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Apalutamide Apalutamide The serum concentration of Pralsetinib can be decreased when it is combined with Apalutamide.
Penicillamine Penicillamine The excretion of Penicillamine can be decreased when combined with Pralsetinib.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Baricitinib Baricitinib The metabolism of Pralsetinib can be increased when combined with Baricitinib.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Pralsetinib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Pralsetinib.
Ivosidenib Ivosidenib The serum concentration of Pralsetinib can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag Pralsetinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The serum concentration of Pralsetinib can be increased when it is combined with Elagolix.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Pralsetinib.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Dacomitinib Dacomitinib The serum concentration of Pralsetinib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib Pralsetinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Pralsetinib.
Sarecycline Sarecycline The serum concentration of Pralsetinib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The serum concentration of Pralsetinib can be increased when it is combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Pralsetinib.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Glasdegib Glasdegib The serum concentration of Pralsetinib can be increased when it is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Pralsetinib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Pralsetinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pralsetinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Pralsetinib.
Rifamycin Rifamycin The serum concentration of Pralsetinib can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Pralsetinib.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Pralsetinib.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Pralsetinib.
Erdafitinib Erdafitinib The serum concentration of Pralsetinib can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Pralsetinib.
Cladribine Cladribine Pralsetinib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Solriamfetol Solriamfetol The excretion of Solriamfetol can be decreased when combined with Pralsetinib.
Darolutamide Darolutamide The serum concentration of Pralsetinib can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Pralsetinib.
Entrectinib Entrectinib The metabolism of Pralsetinib can be increased when combined with Entrectinib.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Pralsetinib.
Istradefylline Istradefylline The serum concentration of Pralsetinib can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Pralsetinib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Pralsetinib can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin Pralsetinib may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be decreased when it is combined with Pralsetinib.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Fosphenytoin can be decreased when it is combined with Pralsetinib.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Pralsetinib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Pralsetinib.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Pralsetinib.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Pralsetinib.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Pralsetinib.
Lasmiditan Lasmiditan The serum concentration of Pralsetinib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Pralsetinib.
Tazemetostat Tazemetostat Pralsetinib may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Bempedoic Acid Bempedoic Acid The excretion of Bempedoic acid can be decreased when combined with Pralsetinib.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Pralsetinib.
Ozanimod Ozanimod Pralsetinib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Pralsetinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Pralsetinib.
Tucatinib Tucatinib Pralsetinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Pralsetinib.
Ripretinib Ripretinib The serum concentration of Pralsetinib can be increased when it is combined with Ripretinib.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Pralsetinib.
Capmatinib Capmatinib The serum concentration of Pralsetinib can be decreased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Pralsetinib.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection Pralsetinib may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Pralsetinib can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Pralsetinib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Pralsetinib.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Pralsetinib.
Indomethacin Indomethacin Pralsetinib may decrease the excretion rate of Indomethacin which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Pralsetinib.
Naproxen Naproxen Pralsetinib may decrease the excretion rate of Naproxen which could result in a higher serum level.
Trazodone Trazodone The metabolism of Trazodone can be decreased when combined with Pralsetinib.
Phenobarbital Phenobarbital The serum concentration of Phenobarbital can be decreased when it is combined with Pralsetinib.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Pralsetinib.
Primidone Primidone The serum concentration of Primidone can be decreased when it is combined with Pralsetinib.
Chlorpromazine Chlorpromazine The risk or severity of liver damage can be increased when Chlorpromazine is combined with Pralsetinib.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Pralsetinib.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Pralsetinib.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Pralsetinib.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Pralsetinib.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Pralsetinib.
Oxycodone Oxycodone The metabolism of Oxycodone can be decreased when combined with Pralsetinib.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Pralsetinib.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Pralsetinib.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Pralsetinib.
Phentermine Phentermine The metabolism of Phentermine can be increased when combined with Pralsetinib.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Pralsetinib.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Pralsetinib.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Pralsetinib.
Carbamazepine Carbamazepine The serum concentration of Carbamazepine can be decreased when it is combined with Pralsetinib.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Pralsetinib.
Prazosin Prazosin Pralsetinib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Cimetidine Cimetidine The risk or severity of liver damage can be increased when Cimetidine is combined with Pralsetinib.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Pralsetinib.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Pralsetinib.
Loperamide Loperamide The serum concentration of Loperamide can be increased when it is combined with Pralsetinib.
Daunorubicin Daunorubicin Pralsetinib may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Pralsetinib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Pralsetinib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The serum concentration of Pralsetinib can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Pralsetinib.
Quinine Quinine The serum concentration of Pralsetinib can be increased when it is combined with Quinine.
Sulfinpyrazone Sulfinpyrazone Pralsetinib may decrease the excretion rate of Sulfinpyrazone which could result in a higher serum level.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Pralsetinib.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Pralsetinib.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Pralsetinib.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Pralsetinib.
Quinidine Quinidine The serum concentration of Pralsetinib can be increased when it is combined with Quinidine.
Procainamide Procainamide The excretion of Procainamide can be decreased when combined with Pralsetinib.
Rifampin Rifampin The serum concentration of Pralsetinib can be decreased when it is combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Pralsetinib.
Tamoxifen Tamoxifen The serum concentration of Tamoxifen can be increased when it is combined with Pralsetinib.
Liothyronine Liothyronine The excretion of Liothyronine can be decreased when combined with Pralsetinib.
Methimazole Methimazole The serum concentration of Pralsetinib can be increased when it is combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Pralsetinib.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Pralsetinib.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Pralsetinib.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Pralsetinib.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Pralsetinib.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Pralsetinib.
Folic Acid Folic Acid Pralsetinib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Disulfiram Disulfiram Pralsetinib may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Pralsetinib.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Pralsetinib.
Spironolactone Spironolactone Pralsetinib may decrease the excretion rate of Spironolactone which could result in a higher serum level.
Nadolol Nadolol The excretion of Nadolol can be decreased when combined with Pralsetinib.
Allopurinol Allopurinol Pralsetinib may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Pralsetinib.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Pralsetinib.
Colchicine Colchicine The serum concentration of Colchicine can be increased when it is combined with Pralsetinib.
Cefaclor Cefaclor Pralsetinib may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection The excretion of Cefazolin can be decreased when combined with Pralsetinib.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Pralsetinib.
Ketoconazole Ketoconazole The serum concentration of Ketoconazole can be increased when it is combined with Pralsetinib.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Pralsetinib.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Pralsetinib.
Captopril Captopril The excretion of Captopril can be decreased when combined with Pralsetinib.
Dipyridamole Dipyridamole Pralsetinib may decrease the excretion rate of Dipyridamole which could result in a higher serum level.
Vinblastine Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Pralsetinib.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Pralsetinib.
Hydroxyzine Hydroxyzine The metabolism of Hydroxyzine can be decreased when combined with Pralsetinib.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Pralsetinib.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Pralsetinib.
Triazolam Triazolam The metabolism of Triazolam can be decreased when combined with Pralsetinib.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Pralsetinib.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Pralsetinib.
Nifedipine Nifedipine Pralsetinib may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Verapamil Verapamil The serum concentration of Pralsetinib can be increased when it is combined with Verapamil.
Atenolol Atenolol Pralsetinib may decrease the excretion rate of Atenolol which could result in a higher serum level.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Pralsetinib.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Pralsetinib.
Glyburide Glyburide Pralsetinib may decrease the excretion rate of Glyburide which could result in a higher serum level.
Glipizide Glipizide Pralsetinib may decrease the excretion rate of Glipizide which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Pralsetinib.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic The excretion of Adefovir dipivoxil can be decreased when combined with Pralsetinib.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Pralsetinib.
Enalapril Enalapril The excretion of Enalapril can be decreased when combined with Pralsetinib.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Pralsetinib.
Amiodarone Amiodarone The serum concentration of Pralsetinib can be increased when it is combined with Amiodarone.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Pralsetinib.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Pralsetinib.
Ciprofloxacin Ciprofloxacin The excretion of Ciprofloxacin can be decreased when combined with Pralsetinib.
Diclofenac Diclofenac Pralsetinib may decrease the excretion rate of Diclofenac which could result in a higher serum level.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Pralsetinib.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Pralsetinib.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Pralsetinib.
Ofloxacin Ofloxacin Pralsetinib may decrease the excretion rate of Ofloxacin which could result in a higher serum level.
Didanosine Didanosine The excretion of Didanosine can be decreased when combined with Pralsetinib.
Clarithromycin Clarithromycin The serum concentration of Clarithromycin can be increased when it is combined with Pralsetinib.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Pralsetinib.
Felodipine Felodipine Pralsetinib may decrease the excretion rate of Felodipine which could result in a higher serum level.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Pralsetinib.
Pravastatin Pravastatin Pralsetinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Pralsetinib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Pralsetinib.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Pralsetinib.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Pralsetinib.
Itraconazole Itraconazole The serum concentration of Pralsetinib can be increased when it is combined with Itraconazole.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Pralsetinib.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Pralsetinib.
Doxazosin Doxazosin The metabolism of Doxazosin can be increased when combined with Pralsetinib.
Isradipine Isradipine Pralsetinib may decrease the excretion rate of Isradipine which could result in a higher serum level.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Pralsetinib.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Pralsetinib.
Venlafaxine Venlafaxine The metabolism of Pralsetinib can be decreased when combined with Venlafaxine.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Pralsetinib.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Pralsetinib.
Fluvoxamine Fluvoxamine Pralsetinib may decrease the excretion rate of Fluvoxamine which could result in a higher serum level.
Nefazodone Nefazodone The serum concentration of Nefazodone can be increased when it is combined with Pralsetinib.
Losartan Losartan Pralsetinib may decrease the excretion rate of Losartan which could result in a higher serum level.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Pralsetinib.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Pralsetinib.
Lansoprazole Lansoprazole Lansoprazole may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Pralsetinib.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Pralsetinib.
Nicardipine Nicardipine Pralsetinib may decrease the excretion rate of Nicardipine which could result in a higher serum level.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Pralsetinib.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be increased when combined with Pralsetinib.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Pralsetinib.
Metformin Metformin The excretion of Metformin can be decreased when combined with Pralsetinib.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Pralsetinib.
Lamivudine Lamivudine Pralsetinib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Pralsetinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Glimepiride Glimepiride Pralsetinib may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Pralsetinib.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Pralsetinib.
Indinavir Indinavir Pralsetinib may decrease the excretion rate of Indinavir which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of Ritonavir can be increased when it is combined with Pralsetinib.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Pralsetinib.
Cidofovir Injection Cidofovir Injection The excretion of Cidofovir can be decreased when combined with Pralsetinib.
Clomipramine Clomipramine The metabolism of Clomipramine can be increased when combined with Pralsetinib.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be increased when combined with Pralsetinib.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Pralsetinib.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Pralsetinib.
Donepezil Donepezil Pralsetinib may decrease the excretion rate of Donepezil which could result in a higher serum level.
Nelfinavir Nelfinavir Pralsetinib may decrease the excretion rate of Nelfinavir which could result in a higher serum level.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Pralsetinib.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Pralsetinib.
Loratadine Loratadine Pralsetinib may decrease the excretion rate of Loratadine which could result in a higher serum level.
Carvedilol Carvedilol The serum concentration of Pralsetinib can be increased when it is combined with Carvedilol.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Pralsetinib.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Pralsetinib.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Pralsetinib.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Pralsetinib.
Propafenone Propafenone The serum concentration of Pralsetinib can be increased when it is combined with Propafenone.
Raloxifene Raloxifene Pralsetinib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Pralsetinib.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Pralsetinib.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Pralsetinib.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Pralsetinib.
Efavirenz Efavirenz The serum concentration of Efavirenz can be increased when it is combined with Pralsetinib.
Sildenafil Sildenafil The serum concentration of Pralsetinib can be increased when it is combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be increased when combined with Pralsetinib.
Celecoxib Celecoxib Pralsetinib may decrease the excretion rate of Celecoxib which could result in a higher serum level.
Rosiglitazone Rosiglitazone Pralsetinib may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Pralsetinib.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Pralsetinib.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Pralsetinib.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Pralsetinib.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists